Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Central Research Institute

Curated by ChEMBL
LigandPNGBDBM50006412((3R,5R)-3,5-dihydroxy-7-((1S,2S,6S,8S,8aR)-6-hydro...)
Affinity DataIC50:  4.20nMAssay Description:In vitro HMG-CoA reductase inhibitory activity of the compound to inhibit sterol synthesis in cell free system in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Central Research Institute

Curated by ChEMBL
LigandPNGBDBM50006412((3R,5R)-3,5-dihydroxy-7-((1S,2S,6S,8S,8aR)-6-hydro...)
Affinity DataIC50:  5nMAssay Description:Inhibition of rat liver microsomal HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Central Research Institute

Curated by ChEMBL
LigandPNGBDBM50006412((3R,5R)-3,5-dihydroxy-7-((1S,2S,6S,8S,8aR)-6-hydro...)
Affinity DataIC50:  1.37E+3nMAssay Description:In vitro HMG-CoA reductase inhibitory activity of the compound to inhibit cellular steroidgenesis in Hep G2 cells (human hepatoma cell line)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed