Compile Data Set for Download or QSAR
maximum 50k data

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 5 hits in this display   

TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50397776(CHEMBL2177187 | US9593129, Example 1)
Affinity DataIC50:  4nMAssay Description:The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...More data for this Ligand-Target Pair
LigandPNGBDBM215050(US9296736, 1)
Affinity DataIC50:  4nMpH: 7.4 T: 2°CAssay Description:The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM215050(US9296736, 1)
Affinity DataIC50:  40nMpH: 7.4 T: 2°CAssay Description:The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50397776(CHEMBL2177187 | US9593129, Example 1)
Affinity DataIC50:  40nMAssay Description:The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...More data for this Ligand-Target Pair
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50397776(CHEMBL2177187 | US9593129, Example 1)
Affinity DataIC50:  4.30E+3nMAssay Description:Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed