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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
5
hits in this display
Target
E3 ubiquitin-protein ligase Mdm2 [1-188]
(Homo sapiens (Human))
Amgen
US Patent
Ligand
BDBM50397776
(CHEMBL2177187 | US9593129, Example 1)
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Affinity Data
IC50: 4nM
Assay Description:
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
US Patent
PDB
3D Structure (crystal)
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Target
Cellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188]
(Homo sapiens (Human))
Amgen
US Patent
Ligand
BDBM215050
(US9296736, 1)
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Affinity Data
IC50: 4nM
pH: 7.4 T: 2°C
Assay Description:
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Cellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188]
(Homo sapiens (Human))
Amgen
US Patent
Ligand
BDBM215050
(US9296736, 1)
Copy SMILES
Copy InChI
Affinity Data
IC50: 40nM
pH: 7.4 T: 2°C
Assay Description:
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
E3 ubiquitin-protein ligase Mdm2 [1-188]
(Homo sapiens (Human))
Amgen
US Patent
Ligand
BDBM50397776
(CHEMBL2177187 | US9593129, Example 1)
Copy SMILES
Copy InChI
Affinity Data
IC50: 40nM
Assay Description:
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
US Patent
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Cellular tumor antigen p53
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50397776
(CHEMBL2177187 | US9593129, Example 1)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.30E+3nM
Assay Description:
Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serum
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
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