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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
11
hits in this display
Target
Estrogen receptor
(Homo sapiens (Human))
Xavier University Of Louisiana
Curated by
ChEMBL
Ligand
BDBM50180684
(4-OHT | Afimoxifene | TamoGel)
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Affinity Data
IC50: 0.530nM
Assay Description:
Displacement of fluormone-labeled ES2 from recombinant full length human ERalpha ligand binding domain expressed in insect cells after 2 hrs by TR-FR...
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Target
Estrogen receptor
(Homo sapiens (Human))
Xavier University Of Louisiana
Curated by
ChEMBL
Ligand
BDBM50180684
(4-OHT | Afimoxifene | TamoGel)
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Affinity Data
IC50: 1.10nM
Assay Description:
Antagonist activity at ERalpha (unknown origin)
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Target
Estrogen receptor
(Homo sapiens (Human))
Xavier University Of Louisiana
Curated by
ChEMBL
Ligand
BDBM50180684
(4-OHT | Afimoxifene | TamoGel)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3nM
Assay Description:
Induction of selective estrogen receptor alpha degradation in human MCF7 cells harboring TK-ERE-Luc assessed as reduction in estradiol-induced transc...
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Target Info
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UniProtKB/SwissProt
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Target
Estrogen receptor beta
(Homo sapiens (Human))
University Of Kragujevac
Curated by
ChEMBL
Ligand
BDBM50180684
(4-OHT | Afimoxifene | TamoGel)
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Affinity Data
IC50: 3.60nM
Assay Description:
Antagonist activity at ERbeta (unknown origin)
More data for this Ligand-Target Pair
Target Info
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antibodypedia
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PubMed
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Target
Estrogen receptor
(Homo sapiens (Human))
Xavier University Of Louisiana
Curated by
ChEMBL
Ligand
BDBM50180684
(4-OHT | Afimoxifene | TamoGel)
Copy SMILES
Copy InChI
Affinity Data
IC50: 10nM
Assay Description:
Induction of selective estrogen receptor alpha degradation in human MCF7 cells harboring TK-ERE-Luc assessed as reduction in estradiol-induced GREB1 ...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
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PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Estrogen receptor
(Homo sapiens (Human))
Xavier University Of Louisiana
Curated by
ChEMBL
Ligand
BDBM50180684
(4-OHT | Afimoxifene | TamoGel)
Copy SMILES
Copy InChI
Affinity Data
IC50: 10nM
Assay Description:
Antagonist activity at ERalpha in human T47D-KBLuc cells assessed as inhibition of E2-induced transcriptional activity by luciferase reporter gene as...
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Target Info
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PC sid
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In Depth
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Article
PubMed
Copy BDB DOI
Target
Estrogen receptor
(Homo sapiens (Human))
Xavier University Of Louisiana
Curated by
ChEMBL
Ligand
BDBM50180684
(4-OHT | Afimoxifene | TamoGel)
Copy SMILES
Copy InChI
Affinity Data
IC50: 70nM
Assay Description:
Antagonist activity at luciferase-fused ERalpha in human HEK293 cells expressing eYFP assessed as reduction of E2-induced estrogenic activity after 2...
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Target Info
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PubMed
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Target
Progesterone receptor
(Homo sapiens (Human))
University Of Kragujevac
Curated by
ChEMBL
Ligand
BDBM50180684
(4-OHT | Afimoxifene | TamoGel)
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Affinity Data
IC50: >100nM
Assay Description:
Antagonist activity at progesterone receptor in human MCF7 cells
More data for this Ligand-Target Pair
Target Info
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Target
Estrogen receptor
(Homo sapiens (Human))
Xavier University Of Louisiana
Curated by
ChEMBL
Ligand
BDBM50180684
(4-OHT | Afimoxifene | TamoGel)
Copy SMILES
Copy InChI
Affinity Data
IC50: >100nM
Assay Description:
Antagonist activity at ERalpha in human MCF7 cells assessed as downregulation of ERalpha
More data for this Ligand-Target Pair
Target Info
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PubMed
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Target
Lysine-specific histone demethylase 1A
(Homo sapiens (Human))
Wuhan University
Curated by
ChEMBL
Ligand
BDBM50180684
(4-OHT | Afimoxifene | TamoGel)
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Affinity Data
IC50: >5.00E+4nM
Assay Description:
Inhibition of LSD1 (unknown origin) incubated for 90 mins by fluorescence based assay
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Target Info
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Target
Aromatase
(Homo sapiens (Human))
State University Of New York Upstate Medical University
Curated by
ChEMBL
Ligand
BDBM50180684
(4-OHT | Afimoxifene | TamoGel)
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Affinity Data
IC50: 5.30E+5nM
Assay Description:
Inhibition of human placental microsomal aromatase using testosterone as substrate assessed as formation of estradiol after 10 mins
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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PC cid
PC sid
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In Depth
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Article
PubMed
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