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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 16 hits in this display   

TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Sharjah

Curated by ChEMBL
LigandPNGBDBM276743(US10071991, Compound (P) | US10800764, Compound (P...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Sharjah

Curated by ChEMBL
LigandPNGBDBM276743(US10071991, Compound (P) | US10800764, Compound (P...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of CSF1R (unknown origin) (538 to 972 residues) expressed in baculovirus expression system using SYEGNSYTFIDPTQ as substrate incubated for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Sharjah

Curated by ChEMBL
LigandPNGBDBM276743(US10071991, Compound (P) | US10800764, Compound (P...)
Affinity DataIC50:  10nMpH: 7.0 T: 2°CAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Sharjah

Curated by ChEMBL
LigandPNGBDBM276743(US10071991, Compound (P) | US10800764, Compound (P...)
Affinity DataIC50:  10nMAssay Description:Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Sharjah

Curated by ChEMBL
LigandPNGBDBM276743(US10071991, Compound (P) | US10800764, Compound (P...)
Affinity DataIC50:  10nMAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Rattus norvegicus (Rat))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276743(US10071991, Compound (P) | US10800764, Compound (P...)
Affinity DataIC50:  11nMAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Rattus norvegicus (Rat))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276743(US10071991, Compound (P) | US10800764, Compound (P...)
Affinity DataIC50:  11nMpH: 7.0 T: 2°CAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Rattus norvegicus (Rat))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276743(US10071991, Compound (P) | US10800764, Compound (P...)
Affinity DataIC50:  11nMAssay Description:Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetReceptor protein-tyrosine kinase(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276743(US10071991, Compound (P) | US10800764, Compound (P...)
Affinity DataIC50:  16nMAssay Description:Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetColony stimulating factor 1 receptor(Canis lupus familiaris (Dog) (Canis familiaris))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276743(US10071991, Compound (P) | US10800764, Compound (P...)
Affinity DataIC50:  16nMpH: 7.0 T: 2°CAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetReceptor protein-tyrosine kinase(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276743(US10071991, Compound (P) | US10800764, Compound (P...)
Affinity DataIC50:  16nMAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Sharjah

Curated by ChEMBL
LigandPNGBDBM276743(US10071991, Compound (P) | US10800764, Compound (P...)
Affinity DataIC50:  18nMAssay Description:c-fms(h) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKSPGEYVNIEFG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Sharjah

Curated by ChEMBL
LigandPNGBDBM276743(US10071991, Compound (P) | US10800764, Compound (P...)
Affinity DataIC50:  18nMAssay Description:c-fms(h) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKSPGEYVNIEFG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Sharjah

Curated by ChEMBL
LigandPNGBDBM276743(US10071991, Compound (P) | US10800764, Compound (P...)
Affinity DataIC50:  18nMAssay Description:c-fms(h) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKSPGEYVNIEFG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Sharjah

Curated by ChEMBL
LigandPNGBDBM276743(US10071991, Compound (P) | US10800764, Compound (P...)
Affinity DataIC50:  18nMpH: 7.0 T: 2°CAssay Description:c-fms(h) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKSPGEYVNIEFG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Sharjah

Curated by ChEMBL
LigandPNGBDBM276743(US10071991, Compound (P) | US10800764, Compound (P...)
Affinity DataIC50:  1.25E+3nMAssay Description:Representative compounds of the present invention were additionally tested in an in vitro assay measuring inhibition of CSF-1 induced monocyte MCP-1 ...More data for this Ligand-Target Pair
In DepthDetails US Patent