Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 32 hits in this display
BDBM276745(US10071991, Compound (I-M2-2R,4S) | US10800764, Co...)
BDBM276745(US10071991, Compound (I-M2-2R,4S) | US10800764, Co...)
BDBM276745(US10071991, Compound (I-M2-2R,4S) | US10800764, Co...)
BDBM276745(US10071991, Compound (I-M2-2R,4S) | US10800764, Co...)
IC50: 2nMAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
BDBM276745(US10071991, Compound (I-M2-2R,4S) | US10800764, Co...)
IC50: 2nMAssay Description:Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...More data for this Ligand-Target Pair
BDBM276745(US10071991, Compound (I-M2-2R,4S) | US10800764, Co...)
IC50: 2nMpH: 7.0 T: 2°CAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
BDBM276744(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
IC50: 2nMpH: 7.0 T: 2°CAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
BDBM276744(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
IC50: 2nMAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
BDBM276744(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
IC50: 2nMAssay Description:Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...More data for this Ligand-Target Pair
BDBM276744(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
IC50: 2.20nMpH: 7.0 T: 2°CAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
BDBM276744(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
IC50: 2.20nMpH: 7.0 T: 2°CAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
BDBM276744(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
IC50: 2.20nMAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
BDBM276744(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
IC50: 2.20nMAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
BDBM276744(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
IC50: 2.20nMAssay Description:Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...More data for this Ligand-Target Pair
BDBM276744(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
IC50: 2.20nMAssay Description:Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...More data for this Ligand-Target Pair
BDBM276745(US10071991, Compound (I-M2-2R,4S) | US10800764, Co...)
IC50: 2.5nMAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
BDBM276745(US10071991, Compound (I-M2-2R,4S) | US10800764, Co...)
IC50: 2.5nMpH: 7.0 T: 2°CAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
BDBM276745(US10071991, Compound (I-M2-2R,4S) | US10800764, Co...)
IC50: 2.5nMAssay Description:Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...More data for this Ligand-Target Pair
BDBM466797(US10800764, Compound (I-M7-2S,4R))
IC50: 6.60nMAssay Description:Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...More data for this Ligand-Target Pair
BDBM276744(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
IC50: 7.10nMAssay Description:Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...More data for this Ligand-Target Pair
BDBM466797(US10800764, Compound (I-M7-2S,4R))
IC50: 7.90nMAssay Description:Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...More data for this Ligand-Target Pair
BDBM466797(US10800764, Compound (I-M7-2S,4R))
IC50: 7.90nMAssay Description:Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...More data for this Ligand-Target Pair
BDBM276744(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
IC50: 8nMAssay Description:Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...More data for this Ligand-Target Pair
BDBM276744(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
IC50: 9.60nMAssay Description:Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...More data for this Ligand-Target Pair
BDBM276741(US10071991, Compound (I-M2) | US10800764, Compound...)
BDBM276741(US10071991, Compound (I-M2) | US10800764, Compound...)
BDBM276741(US10071991, Compound (I-M2) | US10800764, Compound...)
BDBM276741(US10071991, Compound (I-M2) | US10800764, Compound...)
BDBM466797(US10800764, Compound (I-M7-2S,4R))
BDBM276744(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
IC50: 2.37E+3nMAssay Description:Representative compounds of the present invention were additionally tested in an in vitro assay measuring inhibition of CSF-1 induced monocyte MCP-1 ...More data for this Ligand-Target Pair
BDBM276744(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
IC50: 2.93E+3nMAssay Description:Representative compounds of the present invention were additionally tested in an in vitro assay measuring inhibition of CSF-1 induced monocyte MCP-1 ...More data for this Ligand-Target Pair
BDBM276745(US10071991, Compound (I-M2-2R,4S) | US10800764, Co...)
IC50: 8.47E+3nMAssay Description:Representative compounds of the present invention were additionally tested in an in vitro assay measuring inhibition of CSF-1 induced monocyte MCP-1 ...More data for this Ligand-Target Pair