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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
3
hits in this display
Target
Apoptosis regulator Bcl-2
(Homo sapiens (Human))
Abbvie
US Patent
Ligand
BDBM189778
(US11369599, Compound 350 | US9174982, 350)
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Affinity Data
Ki: <0.0100nM ΔG°: <-62.8kJ/mole
T: 2°C
Assay Description:
Representative compounds were serially diluted in dimethyl sulfoxide (DMSO) starting at 50 uM (2x starting concentration; 10% DMSO) and 10 uL were tr...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
Apoptosis regulator Bcl-2
(Homo sapiens (Human))
Abbvie
US Patent
Ligand
BDBM189778
(US11369599, Compound 350 | US9174982, 350)
Copy SMILES
Copy InChI
Affinity Data
Ki: <0.0100nM
Assay Description:
The inhibition constant (Ki) for binding of representative compounds to Bcl-2 protein, as determined by a TR-FRET (Time-Resolved Fluorescence-Resonan...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
Apoptosis regulator Bcl-2
(Homo sapiens (Human))
Abbvie
US Patent
Ligand
BDBM356966
(N-({5-chloro-6-[(cis-1-fluoro-4-hydroxycyclohexyl)...)
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Copy InChI
Affinity Data
Ki: <0.0100nM
Assay Description:
TR-FRET (Time-Resolved Fluorescence-Resonance-Energy-Transfer) assay.
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI