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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
3
hits in this display
Target
1,5-anhydro-D-fructose reductase
(Homo sapiens (Human))
Janssen Pharmaceutica
US Patent
Ligand
BDBM269323
((R)-1-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)me...)
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Affinity Data
IC50: 47.9nM
pH: 7.5 T: 2°C
Assay Description:
10 μL assay buffer (100 mM KH2PO4 pH 7.5) was added to a 384-well clear plate (costar 3702). 0.3 μL compound (at concentrations of 30 μ...
More data for this Ligand-Target Pair
Target Info
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
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Target
Fatty acid synthase
(Homo sapiens (Human))
Janssen Pharmaceutica
US Patent
Ligand
BDBM413528
((R)-1-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)me...)
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Affinity Data
IC50: 55nM
Assay Description:
In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
In Depth
Details
US Patent
Copy BDB DOI
Target
Fatty acid synthase
(Homo sapiens (Human))
Janssen Pharmaceutica
US Patent
Ligand
BDBM269323
((R)-1-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)me...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 55nM
pH: 7.5 T: 2°C
Assay Description:
In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI