Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 18 hits in this display
BDBM50249150(8,15-dimethyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2...)
BDBM50249150(8,15-dimethyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2...)
BDBM50249150(8,15-dimethyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2...)
BDBM50249150(8,15-dimethyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2...)
BDBM50249150(8,15-dimethyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2...)
BDBM50249150(8,15-dimethyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2...)
BDBM50249150(8,15-dimethyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2...)
BDBM50249150(8,15-dimethyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2...)
EC50: >5.00E+3nMAssay Description:Transrepression activity at GR in IL-1-beta-stimulated human A549 cells assessed as inhibition of NF-kappaB-dependent E-selectin transcription by luc...More data for this Ligand-Target Pair
BDBM50249150(8,15-dimethyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2...)
BDBM50249150(8,15-dimethyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2...)
EC50: 117nMAssay Description:Agonist activity at GR ligand binding domain expressed in human NP1 cells assessed as glucocorticoid response element transactivation by GAL4 lucifer...More data for this Ligand-Target Pair
BDBM50249150(8,15-dimethyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2...)
EC50: >1.00E+4nMAssay Description:Agonist activity at GR ligand binding domain expressed in human NP1 cells assessed as glucocorticoid response element transactivation by GAL4 lucifer...More data for this Ligand-Target Pair
BDBM50249150(8,15-dimethyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2...)
EC50: 8.30nMAssay Description:Transrepression activity at GR in IL-1-beta-stimulated human A549 cells assessed as inhibition of NF-kappaB-dependent E-selectin transcription by luc...More data for this Ligand-Target Pair
BDBM50249150(8,15-dimethyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2...)
BDBM50249150(8,15-dimethyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2...)
EC50: 14.7nMAssay Description:Transrepression activity at GR in PMA-stimulated human A549 cells assessed as inhibition of AP1 response element-induced luciferase reporter gene act...More data for this Ligand-Target Pair
BDBM50249150(8,15-dimethyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2...)
EC50: 14.7nMAssay Description:Transrepression activity at GR in PMA-stimulated human A549 cells assessed as inhibition of AP1 response element-induced luciferase reporter gene act...More data for this Ligand-Target Pair
BDBM50249150(8,15-dimethyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2...)
BDBM50249150(8,15-dimethyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2...)
BDBM50249150(8,15-dimethyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2...)
EC50: 117nMAssay Description:Transactivation activity at GR-alpha in human NP1 Hela cells assessed as induction of GAL4-DBD after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair