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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
12
hits in this display
Target
Glucocorticoid receptor
(RAT)
Mitsubishi Kasei
Curated by
ChEMBL
Ligand
BDBM39347
(CLOBETASOL PROPIONATE | MLS000028708 | SMR00005874...)
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Affinity Data
IC50: 3.20nM
Assay Description:
Competitive displacement of [3H]dexamethasone from glucocorticoid receptor of rat liver cytosol
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Target
Cytochrome P450 3A5
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM39347
(CLOBETASOL PROPIONATE | MLS000028708 | SMR00005874...)
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Affinity Data
IC50: 21nM
Assay Description:
Inhibition of CYP3A5 in doxycycline-induced CYP3A5 overexpressing wild type human AsPC1 cells assessed as decrease in 1-hydroxymidazolam formation us...
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Target
Cytochrome P450 3A5
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM39347
(CLOBETASOL PROPIONATE | MLS000028708 | SMR00005874...)
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Affinity Data
IC50: 44nM
Assay Description:
Inhibition of CYP3A5 in wild type human AsPC1 cells assessed as decrease in 1-hydroxymidazolam formation using midazolam as substrate after 24 hrs by...
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Target
Cytochrome P450 3A5
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM39347
(CLOBETASOL PROPIONATE | MLS000028708 | SMR00005874...)
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Affinity Data
IC50: 78nM
Assay Description:
Inhibition of CYP3A5 in lentiviral pLVX-TRE3G-ZsGreen1-CYP3A5 transduced wild type human AsPC1 cells overexpressing CYP3A5 assessed as decrease in 1-...
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Target
Cytochrome P450 3A5
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM39347
(CLOBETASOL PROPIONATE | MLS000028708 | SMR00005874...)
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Affinity Data
IC50: 103nM
Assay Description:
Inhibition of CYP3A5 in CRISPR/Cas9-mediated CYP3A5 knock-out and doxycycline-induced CYP3A5 overexpressing human AsPC1 cells assessed as decrease in...
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Target
Cytochrome P450 3A4
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM39347
(CLOBETASOL PROPIONATE | MLS000028708 | SMR00005874...)
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Affinity Data
IC50: 206nM
Assay Description:
Inhibition of human recombinant CYP3A4 expressed in supersomes assessed as decrease in formation of D-luciferin using luciferin-IPA as substrate incu...
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Target
Bile salt export pump
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM39347
(CLOBETASOL PROPIONATE | MLS000028708 | SMR00005874...)
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Affinity Data
IC50: 8.50E+3nM
Assay Description:
Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
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Target
Bile salt export pump
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM39347
(CLOBETASOL PROPIONATE | MLS000028708 | SMR00005874...)
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Affinity Data
IC50: 8.50E+3nM
Assay Description:
Inhibition of recombinant human BSEP expressed in baculovirus infected sf21 cell plasma membrane vesicles assessed as reduction in ATP-dependent [3H]...
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Target
Cytochrome P450 3A5
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM39347
(CLOBETASOL PROPIONATE | MLS000028708 | SMR00005874...)
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Affinity Data
IC50: 1.56E+4nM
Assay Description:
Inhibition of human recombinant CYP3A5 expressed in supersomes assessed as decrease in formation of D-luciferin using luciferin-IPA as substrate incu...
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Target Info
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Target
Bile salt export pump
(Rattus norvegicus)
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM39347
(CLOBETASOL PROPIONATE | MLS000028708 | SMR00005874...)
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Affinity Data
IC50: 3.50E+4nM
Assay Description:
Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate up...
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Target
Genome polyprotein
(West Nile virus)
University Of Pittsburgh
Curated by
PubChem BioAssay
Ligand
BDBM39347
(CLOBETASOL PROPIONATE | MLS000028708 | SMR00005874...)
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Affinity Data
IC50: >5.00E+4nM
Assay Description:
The HTS assay to identify Inhibitors of West Nile Virus (WNV) NS2bNS3 Proteinase was proposed by Dr Alex Strongin of the Burnham Institute XO1-MH0776...
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Target Info
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PCBioAssay
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Target
Cytochrome P450 3A5
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM39347
(CLOBETASOL PROPIONATE | MLS000028708 | SMR00005874...)
Copy SMILES
Copy InChI
Affinity Data
Kd: 100nM
Assay Description:
Binding affinity to heme in His-tagged CYP3A5 (unknown origin) expressed in Escherichia coli DH5alpha assessed as changes in absorbance spectra of he...
More data for this Ligand-Target Pair
Target Info
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ChEBI
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MCE
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In Depth
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PDB
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