Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

TargetBeta-secretase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

LigandBDBM50352851(CHEMBL1824362)Copy SMILESCopy InChI

Affinity DataIC50:  5.45E+3nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPatentsSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetCathepsin D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

LigandBDBM50352851(CHEMBL1824362)Copy SMILESCopy InChI

Affinity DataIC50:  7.84E+4nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPatentsSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

LigandBDBM50352851(CHEMBL1824362)Copy SMILESCopy InChI

Affinity DataEC50:  2.90E+3nMAssay Description:Inhibition of BACE1 expressed in CHO cells expressing wild type human APP assessed as inhibition of amyloid beta-40 or 42 production by ELISA assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPatentsSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI