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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
6
hits in this display
Target
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50448946
(CHEMBL3125709 | US9593129, Example 150)
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Affinity Data
IC50: 1.20nM
Assay Description:
Binding affinity to human GST-thrombin-tagged MDM2 assessed as inhibition of interaction with human p53 after 1 hr by HTRF assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188]
(Homo sapiens (Human))
Amgen
US Patent
Ligand
BDBM215195
(US9296736, 150)
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Copy InChI
Affinity Data
IC50: 2nM
pH: 7.4 T: 2°C
Assay Description:
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
E3 ubiquitin-protein ligase Mdm2 [1-188]
(Homo sapiens (Human))
Amgen
US Patent
Ligand
BDBM50448946
(CHEMBL3125709 | US9593129, Example 150)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2nM
Assay Description:
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
E3 ubiquitin-protein ligase Mdm2 [1-188]
(Homo sapiens (Human))
Amgen
US Patent
Ligand
BDBM50448946
(CHEMBL3125709 | US9593129, Example 150)
Copy SMILES
Copy InChI
Affinity Data
IC50: 10nM
Assay Description:
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
Cellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188]
(Homo sapiens (Human))
Amgen
US Patent
Ligand
BDBM215195
(US9296736, 150)
Copy SMILES
Copy InChI
Affinity Data
IC50: 10nM
pH: 7.4 T: 2°C
Assay Description:
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50448946
(CHEMBL3125709 | US9593129, Example 150)
Copy SMILES
Copy InChI
Affinity Data
IC50: 22nM
Assay Description:
Binding affinity to human GST-thrombin-tagged MDM2 assessed as inhibition of interaction with human p53 after 1 hr by HTRF assay in presence of 15% h...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI