Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 14 hits in this display   

TargetWD repeat-containing protein 5(Homo sapiens (Human))
Zhejiang Sci-Tech University

Curated by ChEMBL

LigandBDBM200723(US9233086, 10L)Copy SMILESCopy InChI

Affinity DataKi: <1nMAssay Description:Displacement of 5-FAM labelled tracer from WDR5 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails ArticlePubMed
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TargetHistone-lysine N-methyltransferase 2A(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

LigandBDBM200723(US9233086, 10L)Copy SMILESCopy InChI

Affinity DataKi: <1nMAssay Description:Inhibition of MLL1 binding to N-terminal His-tagged WRD5 23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli Roset...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails ArticlePubMed
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TargetWD repeat-containing protein 5(Homo sapiens (Human))
Zhejiang Sci-Tech University

Curated by ChEMBL

LigandBDBM200723(US9233086, 10L)Copy SMILESCopy InChI

Affinity DataIC50:  1.70nMAssay Description:Inhibition of 10mer-Thr-FAM probe binding to human WDR5 after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetWD repeat-containing protein 5(Homo sapiens (Human))
Zhejiang Sci-Tech University

Curated by ChEMBL

LigandBDBM200723(US9233086, 10L)Copy SMILESCopy InChI

Affinity DataIC50:  2.40nMAssay Description:Inhibition of C-terminal 5-FAM-WIN peptide binding to N-terminal His-tagged WDR5 (24 to 334 residues) (unknown origin) expressed in Rosetta2-(DE3) pL...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetWD repeat-containing protein 5(Homo sapiens (Human))
Zhejiang Sci-Tech University

Curated by ChEMBL

LigandBDBM200723(US9233086, 10L)Copy SMILESCopy InChI

Affinity DataIC50:  2.40nMAssay Description:Inhibition of fluorescence-labeled Ac-ARA peptide binding to WDR5 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetWD repeat-containing protein 5(Homo sapiens (Human))
Zhejiang Sci-Tech University

Curated by ChEMBL

LigandBDBM200723(US9233086, 10L)Copy SMILESCopy InChI

Affinity DataIC50:  2.40nMAssay Description:Inhibition of WDR5 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetWD repeat-containing protein 5(Homo sapiens (Human))
Zhejiang Sci-Tech University

Curated by ChEMBL

LigandBDBM200723(US9233086, 10L)Copy SMILESCopy InChI

Affinity DataIC50:  2.40nMAssay Description:Displacement of fluorescence-labelled Ac-ARA peptide from WDR5 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetHistone-lysine N-methyltransferase 2A(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

LigandBDBM200723(US9233086, 10L)Copy SMILESCopy InChI

Affinity DataIC50:  2.40nMAssay Description:Inhibition of MLL1 binding to N-terminal His-tagged WRD5 23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli Roset...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetWD repeat-containing protein 5(Homo sapiens (Human))
Zhejiang Sci-Tech University

Curated by ChEMBL

LigandBDBM200723(US9233086, 10L)Copy SMILESCopy InChI

Affinity DataIC50:  2.40nMAssay Description:Binding affinity to WDR5 (unknown origin) fluorescence polarization assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails PubMed
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TargetHistone-lysine N-methyltransferase 2A/Retinoblastoma-binding protein 5/Set1/Ash2 histone methyltransferase complex subunit ASH2/WD repeat-containing protein 5(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

LigandBDBM200723(US9233086, 10L)Copy SMILESCopy InChI

Affinity DataIC50:  400nMAssay Description:Inhibition of His-SUMO-fused MLL1 (3762 to 3969 residues) interaction with His-SUMO-fused ASH2L/RBBP5/WDR5 (23 to 334 residues) (unknown origin) expr...More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetHistone-lysine N-methyltransferase 2A/Retinoblastoma-binding protein 5/Set1/Ash2 histone methyltransferase complex subunit ASH2/WD repeat-containing protein 5(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

LigandBDBM200723(US9233086, 10L)Copy SMILESCopy InChI

Affinity DataIC50:  400nMAssay Description:Inhibition of recombinant SUMO-fused MLL1/ASH2L/RBBP5/WDR5 complex histone methyltransferase activity (unknown origin) expressed in Escherichia coli ...More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetHistone-lysine N-methyltransferase 2A/Retinoblastoma-binding protein 5/Set1/Ash2 histone methyltransferase complex subunit ASH2/WD repeat-containing protein 5(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

LigandBDBM200723(US9233086, 10L)Copy SMILESCopy InChI

Affinity DataIC50:  750nMAssay Description:Inhibition of recombinant MLL1/ASH2L/RBBP5/WDR5 complex histone methyltransferase activity (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetHistone-lysine N-methyltransferase 2A/Retinoblastoma-binding protein 5/Set1/Ash2 histone methyltransferase complex subunit ASH2/WD repeat-containing protein 5(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

LigandBDBM200723(US9233086, 10L)Copy SMILESCopy InChI

Affinity DataIC50:  900nMAssay Description:Inhibition of recombinant MLL1 (unknown origin) interaction with recombinant ASH2L/RBBP5/WDR5 (unknown origin) assessed as decrease in histone methyl...More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetWD repeat-containing protein 5 [24-334](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent

LigandBDBM200723(US9233086, 10L)Copy SMILESCopy InChI

Affinity DataIC50: <3.00E+3nMpH: 6.5 T: 2°CAssay Description:N-terminal His-tagged WDR5Δ23 (residues 24-334) was expressed from the pET28-MHL vector in Rosetta2(DE3) pLysS cells (Novagen). Cells were grown...More data for this Ligand-Target Pair

Target InfoPDBMMDB
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sid

In DepthDetails US Patent
Copy BDB DOI