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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
3
hits in this display
Target
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human))
Jiangsu University
Curated by
ChEMBL
Ligand
BDBM50197508
(CHEMBL3889954)
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Affinity Data
IC50: 220nM
Assay Description:
Inhibition of recombinant human GST or His6-tagged SIRT1 using H2N-HK-[Nepsilon-acetyl-lysine]-LM-COOH as substrate incubated for 10 mins in presence...
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human))
Jiangsu University
Curated by
ChEMBL
Ligand
BDBM50197508
(CHEMBL3889954)
Copy SMILES
Copy InChI
Affinity Data
IC50: 240nM
Assay Description:
Inhibition of recombinant human His6-tagged SIRT2 using H2N-HK-[Nepsilon-acetyl-lysine]-LM-COOH as substrate incubated for 12 mins in presence of bet...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
(Homo sapiens (Human))
Jiangsu University
Curated by
ChEMBL
Ligand
BDBM50197508
(CHEMBL3889954)
Copy SMILES
Copy InChI
Affinity Data
IC50: 470nM
Assay Description:
Inhibition of recombinant human His6-tagged SIRT3 using H2N-HK-[Nepsilon-acetyl-lysine]-LM-COOH as substrate incubated for 10 mins in presence of bet...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI