Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 4 hits in this display   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Naples

Curated by ChEMBL
LigandPNGBDBM50078863(CHEMBL3416180)
Affinity DataIC50:  320nMAssay Description:Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation pre-incubated for 15 mins followed...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Naples

Curated by ChEMBL
LigandPNGBDBM50078863(CHEMBL3416180)
Affinity DataIC50:  570nMAssay Description:Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Naples

Curated by ChEMBL
LigandPNGBDBM50078863(CHEMBL3416180)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 incubated for 10 mins in presence of arachidonic acid by RP-HPLC based cell-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-expressed gene 1 protein(Homo sapiens (Human))
University Of Naples

Curated by ChEMBL
LigandPNGBDBM50078863(CHEMBL3416180)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed