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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
20
hits in this display
Target
Histone acetyltransferase KAT8
(Homo sapiens (Human))
University Of Groningen
Curated by
ChEMBL
Ligand
BDBM50240436
(2-Hydroxy-6-pentadecyl-benzoic acid | 2-hydroxy-6-...)
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Affinity Data
Ki: 6.40E+4nM
Assay Description:
Inhibition of recombinant N-terminal His6-tagged KAT8 (unknown origin) expressed in Escherichia Coli BL21 DE3 cells assessed as reduction of Co A lev...
More data for this Ligand-Target Pair
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Target
SUMO-activating enzyme subunit 1
(Homo sapiens (Human))
University Of Toronto Mississauga
Curated by
ChEMBL
Ligand
BDBM50240436
(2-Hydroxy-6-pentadecyl-benzoic acid | 2-hydroxy-6-...)
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Affinity Data
IC50: 2.20E+3nM
Assay Description:
Inhibition of recombinant SAE1(unknown origin)-mediated SUMOylation of RanGAP1-C2
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Target
Histone acetyltransferase p300
(Homo sapiens (Human))
University Of Freiburg
Curated by
ChEMBL
Ligand
BDBM50240436
(2-Hydroxy-6-pentadecyl-benzoic acid | 2-hydroxy-6-...)
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Affinity Data
IC50: 4.15E+3nM
Assay Description:
Inhibition of recombinant p300 catalytic domain (unknown origin) using N-terminal histone H3 substrate by radiometric filter binding assay in presenc...
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Target
Histone acetyltransferase KAT2B
(Homo sapiens (Human))
University Of Freiburg
Curated by
ChEMBL
Ligand
BDBM50240436
(2-Hydroxy-6-pentadecyl-benzoic acid | 2-hydroxy-6-...)
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Affinity Data
IC50: 5.00E+3nM
Assay Description:
Inhibition of full length recombinant human FLAG-tagged PCAF expressed in baculovirus infected Sf21 cells using N-terminal H3 peptide substrate after...
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Target Info
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Target
Histone acetyltransferase KAT2B
(Homo sapiens (Human))
University Of Freiburg
Curated by
ChEMBL
Ligand
BDBM50240436
(2-Hydroxy-6-pentadecyl-benzoic acid | 2-hydroxy-6-...)
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Affinity Data
IC50: 5.00E+3nM
Assay Description:
Inhibition of recombinant FLAG epitope-tagged human PCAF expressed in Baculovirus-infected Sf21 cells using histone peptide as substrate after 10 min...
More data for this Ligand-Target Pair
Target Info
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Target
Replicase polyprotein 1ab
(2019-nCoV)
University Of Colorado
Curated by
ChEMBL
Ligand
BDBM50240436
(2-Hydroxy-6-pentadecyl-benzoic acid | 2-hydroxy-6-...)
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Affinity Data
IC50: 6.80E+3nM
Assay Description:
Inhibition of SARS-CoV-2 main protease expressed in Escherichia coli using DABCYL-KTSAVLQ1SGFRKM-E(EDANS)-NH2 peptide as substrate incubated for 30 m...
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Target Info
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Target
Histone acetyltransferase p300
(Homo sapiens (Human))
University Of Freiburg
Curated by
ChEMBL
Ligand
BDBM50240436
(2-Hydroxy-6-pentadecyl-benzoic acid | 2-hydroxy-6-...)
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Affinity Data
IC50: 8.50E+3nM
Assay Description:
Inhibition of recombinant His6-tagged human P300 expressed in Baculovirus-infected Sf21 cells using histone peptide as substrate after 10 mins in pre...
More data for this Ligand-Target Pair
Target Info
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Target
Histone acetyltransferase p300
(Homo sapiens (Human))
University Of Freiburg
Curated by
ChEMBL
Ligand
BDBM50240436
(2-Hydroxy-6-pentadecyl-benzoic acid | 2-hydroxy-6-...)
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Affinity Data
IC50: 8.50E+3nM
Assay Description:
Inhibition of recombinant human full-length His6-tagged p300 expressed in baculovirus infected Sf21 insect cells using [3H]acetylCoA as substrate pre...
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Histone acetyltransferase p300
(Homo sapiens (Human))
University Of Freiburg
Curated by
ChEMBL
Ligand
BDBM50240436
(2-Hydroxy-6-pentadecyl-benzoic acid | 2-hydroxy-6-...)
Copy SMILES
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Affinity Data
IC50: 8.50E+3nM
Assay Description:
Inhibition of full length recombinant human His6-tagged p300 expressed in baculovirus infected Sf21 cells using N-terminal H3 peptide substrate after...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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Target
Replicase polyprotein 1ab
(2019-nCoV)
University Of Colorado
Curated by
ChEMBL
Ligand
BDBM50240436
(2-Hydroxy-6-pentadecyl-benzoic acid | 2-hydroxy-6-...)
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Affinity Data
IC50: 1.10E+4nM
Assay Description:
The 3CLpro enzyme assay was developed in 384-well black, medium binding microplates (Greiner Bio-One, Monroe, NC, USA) with a total volume of 20 _...
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Target Info
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Target
Histone acetyltransferase KAT2B
(Homo sapiens (Human))
University Of Freiburg
Curated by
ChEMBL
Ligand
BDBM50240436
(2-Hydroxy-6-pentadecyl-benzoic acid | 2-hydroxy-6-...)
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Affinity Data
IC50: 3.39E+4nM
Assay Description:
Inhibition of recombinant human PCAF catalytic domain (492 to 658 residues) using histone H3 peptide substrate after 1 hr by liquid scintillation cou...
More data for this Ligand-Target Pair
Target Info
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Target
Probable linoleate 9S-lipoxygenase 5
(Solanum tuberosum)
Groningen Research Institute Of Pharmacy
Curated by
ChEMBL
Ligand
BDBM50240436
(2-Hydroxy-6-pentadecyl-benzoic acid | 2-hydroxy-6-...)
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Affinity Data
IC50: 4.30E+4nM
Assay Description:
Inhibition of potato 5-lipoxygenase assessed as residual activity preincubated for 10 mins measured by real-time spectrophotometric analysis
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Target
Histone acetyltransferase KAT8
(Homo sapiens (Human))
University Of Groningen
Curated by
ChEMBL
Ligand
BDBM50240436
(2-Hydroxy-6-pentadecyl-benzoic acid | 2-hydroxy-6-...)
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Affinity Data
IC50: 4.30E+4nM
Assay Description:
Inhibition of MOF (unknown origin)
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Target
Seed linoleate 13S-lipoxygenase-1
(Glycine max (soybean))
Groningen Research Institute Of Pharmacy
Curated by
ChEMBL
Ligand
BDBM50240436
(2-Hydroxy-6-pentadecyl-benzoic acid | 2-hydroxy-6-...)
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Affinity Data
IC50: 5.19E+4nM
Assay Description:
Inhibition of soyabean lipoxygenase-1 assessed as formation of 13-HPOD from linolenic acid preincubated for 10 mins measured by real-time spectrophot...
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Target
Histone acetyltransferase KAT5
(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50240436
(2-Hydroxy-6-pentadecyl-benzoic acid | 2-hydroxy-6-...)
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Affinity Data
IC50: 6.40E+4nM
Assay Description:
Inhibition of Tip60 (unknown origin)
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Target Info
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Target
Seed linoleate 13S-lipoxygenase-1
(Glycine max (soybean))
Groningen Research Institute Of Pharmacy
Curated by
ChEMBL
Ligand
BDBM50240436
(2-Hydroxy-6-pentadecyl-benzoic acid | 2-hydroxy-6-...)
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Affinity Data
IC50: 8.50E+4nM
Assay Description:
Inhibition of soybean lipoxygenase-1
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Target Info
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Target
Histone acetyltransferase KAT8
(Homo sapiens (Human))
University Of Groningen
Curated by
ChEMBL
Ligand
BDBM50240436
(2-Hydroxy-6-pentadecyl-benzoic acid | 2-hydroxy-6-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.14E+11nM
Assay Description:
Inhibition of recombinant N-terminal His6-tagged KAT8 (unknown origin) expressed in Escherichia Coli BL21 DE3 cells assessed as reduction of Co A lev...
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
Replicase polyprotein 1ab
(2019-nCoV)
University Of Colorado
Curated by
ChEMBL
Ligand
BDBM50240436
(2-Hydroxy-6-pentadecyl-benzoic acid | 2-hydroxy-6-...)
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Affinity Data
EC50: 3.98E+3nM
Assay Description:
SARS-CoV-2 CPE assay was conducted at Southern Research Institute (Birmingham, AL) as described in previous reports30, 31. In brief, high ACE2 expres...
More data for this Ligand-Target Pair
Target Info
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Target
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human))
University Of Toronto
Curated by
ChEMBL
Ligand
BDBM50240436
(2-Hydroxy-6-pentadecyl-benzoic acid | 2-hydroxy-6-...)
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Affinity Data
EC50: 1.70E+4nM
Assay Description:
Agonist activity at human PPARgamma expressed in HEK293 cells by luciferase/beta-galactosidase reporter gene assay
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
University Of Toronto
Curated by
ChEMBL
Ligand
BDBM50240436
(2-Hydroxy-6-pentadecyl-benzoic acid | 2-hydroxy-6-...)
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Affinity Data
EC50: 3.50E+3nM
Assay Description:
Agonist activity at human PPARalpha expressed in HEK293 cells by luciferase/beta-galactosidase reporter gene assay
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