Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 8 hits in this display   

TargetCholinesterase(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna

Curated by ChEMBL
LigandPNGBDBM10925(3-{[methyl({3-[(2-oxo-2H-chromen-7-yl)oxy]propyl})...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human serum BuChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by Ellman's meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of Bologna

LigandPNGBDBM10925(3-{[methyl({3-[(2-oxo-2H-chromen-7-yl)oxy]propyl})...)
Affinity DataIC50:  13nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Alma Mater Studiorum-University Of Bologna

Curated by ChEMBL
LigandPNGBDBM10925(3-{[methyl({3-[(2-oxo-2H-chromen-7-yl)oxy]propyl})...)
Affinity DataIC50:  29nMAssay Description:Inhibition of FAAH in rat brain membrane using N-arachidonoyl-[14C]-ethanolamine as substrate preincubated for 20 mins followed by substrate addition...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of Bologna

LigandPNGBDBM10925(3-{[methyl({3-[(2-oxo-2H-chromen-7-yl)oxy]propyl})...)
Affinity DataIC50:  37nMAssay Description:Inhibition of recombinant human AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 120 mins followed by subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna

Curated by ChEMBL
LigandPNGBDBM10925(3-{[methyl({3-[(2-oxo-2H-chromen-7-yl)oxy]propyl})...)
Affinity DataIC50:  65nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Alma Mater Studiorum-University Of Bologna

Curated by ChEMBL
LigandPNGBDBM10925(3-{[methyl({3-[(2-oxo-2H-chromen-7-yl)oxy]propyl})...)
Affinity DataIC50:  161nMAssay Description:Inhibition of FAAH in rat brain membrane using N-arachidonoyl-[14C]-ethanolamine as substrate incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Alma Mater Studiorum-University Of Bologna

Curated by ChEMBL
LigandPNGBDBM10925(3-{[methyl({3-[(2-oxo-2H-chromen-7-yl)oxy]propyl})...)
Affinity DataIC50:  170nMAssay Description:Inhibition of FAAH in rat brain membranes assessed as hydrolysis of [14C]-anandamide preincubated for 20 mins before [14C]-anandamide addition measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Alma Mater Studiorum-University Of Bologna

Curated by ChEMBL
LigandPNGBDBM10925(3-{[methyl({3-[(2-oxo-2H-chromen-7-yl)oxy]propyl})...)
Affinity DataIC50:  620nMAssay Description:Inhibition of FAAH in rat brain membranes assessed as hydrolysis of [14C]-anandamide after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed