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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
8
hits in this display
Target
Cholinesterase
(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna
Curated by
ChEMBL
Ligand
BDBM10925
(3-{[methyl({3-[(2-oxo-2H-chromen-7-yl)oxy]propyl})...)
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Affinity Data
IC50: 1.40nM
Assay Description:
Inhibition of human serum BuChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by Ellman's meth...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Acetylcholinesterase
(Homo sapiens (Human))
University Of Bologna
Ligand
BDBM10925
(3-{[methyl({3-[(2-oxo-2H-chromen-7-yl)oxy]propyl})...)
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Affinity Data
IC50: 13nM
pH: 8.0 T: 2°C
Assay Description:
The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat))
Alma Mater Studiorum-University Of Bologna
Curated by
ChEMBL
Ligand
BDBM10925
(3-{[methyl({3-[(2-oxo-2H-chromen-7-yl)oxy]propyl})...)
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Affinity Data
IC50: 29nM
Assay Description:
Inhibition of FAAH in rat brain membrane using N-arachidonoyl-[14C]-ethanolamine as substrate preincubated for 20 mins followed by substrate addition...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Acetylcholinesterase
(Homo sapiens (Human))
University Of Bologna
Ligand
BDBM10925
(3-{[methyl({3-[(2-oxo-2H-chromen-7-yl)oxy]propyl})...)
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Copy InChI
Affinity Data
IC50: 37nM
Assay Description:
Inhibition of recombinant human AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 120 mins followed by subs...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cholinesterase
(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna
Curated by
ChEMBL
Ligand
BDBM10925
(3-{[methyl({3-[(2-oxo-2H-chromen-7-yl)oxy]propyl})...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 65nM
Assay Description:
The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat))
Alma Mater Studiorum-University Of Bologna
Curated by
ChEMBL
Ligand
BDBM10925
(3-{[methyl({3-[(2-oxo-2H-chromen-7-yl)oxy]propyl})...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 161nM
Assay Description:
Inhibition of FAAH in rat brain membrane using N-arachidonoyl-[14C]-ethanolamine as substrate incubated for 30 mins by scintillation counting method
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat))
Alma Mater Studiorum-University Of Bologna
Curated by
ChEMBL
Ligand
BDBM10925
(3-{[methyl({3-[(2-oxo-2H-chromen-7-yl)oxy]propyl})...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 170nM
Assay Description:
Inhibition of FAAH in rat brain membranes assessed as hydrolysis of [14C]-anandamide preincubated for 20 mins before [14C]-anandamide addition measur...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat))
Alma Mater Studiorum-University Of Bologna
Curated by
ChEMBL
Ligand
BDBM10925
(3-{[methyl({3-[(2-oxo-2H-chromen-7-yl)oxy]propyl})...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 620nM
Assay Description:
Inhibition of FAAH in rat brain membranes assessed as hydrolysis of [14C]-anandamide after 30 mins
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI