Compile Data Set for Download or QSAR
maximum 50k data

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 7 hits in this display   

TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50153442(CHEMBL3774442 | US9630914, Example 18)
Affinity DataIC50:  30nMAssay Description:Inhibition of ovine COX1 assessed as production of PGF2-alpha preincubated with compound followed by the addition of 5 uM arachidonic acid as substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50153442(CHEMBL3774442 | US9630914, Example 18)
Affinity DataIC50:  30nMAssay Description:COX activity was measured using a commercial kit (COX Inhibitor Screening Assay Kit Cayman Chemical N. 560131) which includes both ovine COX-1 and hu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50153442(CHEMBL3774442 | US9630914, Example 18)
Affinity DataIC50:  170nMAssay Description:Inhibition of recombinant human COX2 assessed as production of PGF2-alpha preincubated with compound followed by the addition of 5 uM arachidonic aci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50153442(CHEMBL3774442 | US9630914, Example 18)
Affinity DataIC50:  170nMAssay Description:COX activity was measured using a commercial kit (COX Inhibitor Screening Assay Kit Cayman Chemical N. 560131) which includes both ovine COX-1 and hu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50153442(CHEMBL3774442 | US9630914, Example 18)
Affinity DataIC50:  1.49E+4nMAssay Description:Inhibition of FAAH in Sprague-Dawley rat brain homogenates preincubated for 10 mins followed by addition of substrate measured after 30 mins by liqui...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Fondazione Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50153442(CHEMBL3774442 | US9630914, Example 18)
Affinity DataIC50:  1.50E+4nMAssay Description:Rat FAAH was prepared from male Sprague Dawley rat brains, homogenized in a potter in 20 mM of Tris HCl pH 7.4, 0.32 M sucrose.The radiometric assay ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Fondazione Istituto Italiano Di Tecnologia

US Patent
LigandPNGBDBM50153442(CHEMBL3774442 | US9630914, Example 18)
Affinity DataIC50:  2.10E+4nMAssay Description:Human recombinant FAAH was obtained from a HEK-293 FAAH-1 overexpressing stable cell line. Cells were grown in DMEM medium containing 10% FBS, 1% pen...More data for this Ligand-Target Pair
In DepthDetails US Patent