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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 4 hits in this display   

TargetBcl-2-like protein 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50384361(CHEMBL2031031 | US9346795, 96)
Affinity DataIC50:  60nMT: 2°CAssay Description:The assays were performed in black flat-bottom 384-well plates. The final assay volume was 55 μl prepared from additions of Biotin-Bcl-xL (Bcl-x...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBcl-2-like protein 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50384361(CHEMBL2031031 | US9346795, 96)
Affinity DataIC50:  62nMAssay Description:Inhibition of Bcl-XL using fluoresceinated 18-mer Bim as substrate after 60 mins by FRET analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50384361(CHEMBL2031031 | US9346795, 96)
Affinity DataIC50:  120nMAssay Description:Inhibition in GST-tagged Bcl2 using [FAM]-IWIAQELRRIGDEFNAYY-NH2 as substrate after 60 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50384361(CHEMBL2031031 | US9346795, 96)
Affinity DataIC50:  120nMT: 2°CAssay Description:The assays were performed in black flat-bottom 384-well plates. The final assay volume was 50 μl prepared from additions of Gst-Bcl-2 (Bcl-2: GE...More data for this Ligand-Target Pair
In DepthDetails US Patent