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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
6
hits in this display
Target
Metabotropic glutamate receptor 2
(Homo sapiens (Human))
Janssen Pharmaceutica
Curated by
ChEMBL
Ligand
BDBM50051408
(CHEMBL3337527 | US11071729, Compound 2)
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Affinity Data
Ki: 180nM
Assay Description:
Displacement of [3H]8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-phenyl-1-piperidinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine from mGlu2 receptor (unkno...
More data for this Ligand-Target Pair
Target Info
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GoogleScholar
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CHEMBL
MCE
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Article
PubMed
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3D Structure (crystal)
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Target
Metabotropic glutamate receptor 2
(Homo sapiens (Human))
Janssen Pharmaceutica
Curated by
ChEMBL
Ligand
BDBM50051408
(CHEMBL3337527 | US11071729, Compound 2)
Copy SMILES
Copy InChI
Affinity Data
IC50: 68nM
Assay Description:
Displacement of [3H]19 from human mGlu2 receptor expressed in CHO cells
More data for this Ligand-Target Pair
Target Info
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UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
MCE
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Metabotropic glutamate receptor 2
(Homo sapiens (Human))
Janssen Pharmaceutica
Curated by
ChEMBL
Ligand
BDBM50051408
(CHEMBL3337527 | US11071729, Compound 2)
Copy SMILES
Copy InChI
Affinity Data
EC50: 147nM
Assay Description:
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as potentiation of glutamate-induced effect incubated for 30 m...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Metabotropic glutamate receptor 2
(Homo sapiens (Human))
Janssen Pharmaceutica
Curated by
ChEMBL
Ligand
BDBM50051408
(CHEMBL3337527 | US11071729, Compound 2)
Copy SMILES
Copy InChI
Affinity Data
EC50: 182nM
Assay Description:
Measurement of mGluR2 positive allosteric modulatory activity of test compounds in membranes containing human mGluR2 was performed using frozen membr...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
Similars
In Depth
Details
US Patent
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Metabotropic glutamate receptor 2
(Homo sapiens (Human))
Janssen Pharmaceutica
Curated by
ChEMBL
Ligand
BDBM50051408
(CHEMBL3337527 | US11071729, Compound 2)
Copy SMILES
Copy InChI
Affinity Data
EC50: 65nM
Assay Description:
Positive allosteric modulation of wild-type human mGlu2 receptor expressed in CHO-K1 cells assessed as potentiation of glutamate-induced effect incub...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Metabotropic glutamate receptor 2
(Homo sapiens (Human))
Janssen Pharmaceutica
Curated by
ChEMBL
Ligand
BDBM50051408
(CHEMBL3337527 | US11071729, Compound 2)
Copy SMILES
Copy InChI
Affinity Data
EC50: 147nM
Assay Description:
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cell membranes assessed as potentiation of glutamate-induced effect incubated...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI