Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 7 hits in this display
BDBM197677(US9216981, 5 | US9550781, 1)
IC50: 9nMAssay Description:Inhibition of B-Raf V600E mutant (unknown origin) assessed as MEK1 phosphorylation using MEK1-Avitag as substrate after 1 hr by HTRF assayMore data for this Ligand-Target Pair
BDBM197677(US9216981, 5 | US9550781, 1)
IC50: 12nMAssay Description:Inhibition of wild type B-Raf (unknown origin) assessed as MEK1 phosphorylation using MEK1-Avitag as substrate after 1 hr by HTRF assayMore data for this Ligand-Target Pair
BDBM197677(US9216981, 5 | US9550781, 1)
BDBM197677(US9216981, 5 | US9550781, 1)
IC50: 24nMAssay Description:Inhibition of B-Raf V600E mutant in human A375 cells assessed as ERK phosphorylation preincubated for 1 hr by Western blot methodMore data for this Ligand-Target Pair
BDBM197677(US9216981, 5 | US9550781, 1)
BDBM197677(US9216981, 5 | US9550781, 1)
BDBM197677(US9216981, 5 | US9550781, 1)
EC50: 936nMAssay Description:Inhibition of wild type B-Raf in human MIAPaCa2 cells assessed as reduction in ERK phosphorylation preincubated for 1 hr by Western blot methodMore data for this Ligand-Target Pair