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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
24
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Target
Peroxisome proliferator-activated receptor delta
(Homo sapiens (Human))
Marquette University
Curated by
ChEMBL
Ligand
BDBM50085041
(2-(4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propox...)
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Affinity Data
IC50: 13nM
Assay Description:
Agonist activity at GAL4 DNA-binding domain fused PPARdelta receptor (unknown origin) ligand binding domain expressed in UAS-bla HEK 293T cells asses...
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Target
Peroxisome proliferator-activated receptor delta
(Homo sapiens (Human))
Marquette University
Curated by
ChEMBL
Ligand
BDBM50085041
(2-(4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propox...)
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Affinity Data
EC50: 50nM
Assay Description:
Agonist activity at PPARdelta (unknown origin)
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Target
Peroxisome proliferator-activated receptor delta
(Mus musculus)
Glaxo Wellcome Research & Development
Curated by
ChEMBL
Ligand
BDBM50085041
(2-(4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propox...)
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Affinity Data
EC50: 3.80E+3nM
Assay Description:
Agonist activity for murine PPAR delta receptor in transcriptional activation assay
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Target
Peroxisome proliferator-activated receptor gamma
(Mus musculus)
Glaxo Wellcome Research & Development
Curated by
ChEMBL
Ligand
BDBM50085041
(2-(4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propox...)
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Affinity Data
EC50: 1.00E+4nM
Assay Description:
Agonist activity for murine PPAR gamma receptor in transcriptional activation assay
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Target
Peroxisome proliferator-activated receptor delta
(Homo sapiens (Human))
Marquette University
Curated by
ChEMBL
Ligand
BDBM50085041
(2-(4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propox...)
Copy SMILES
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Affinity Data
EC50: 530nM
Assay Description:
Agonist activity for Human PPAR delta receptor in transcriptional activation assay
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Glaxo Wellcome Research & Development
Curated by
ChEMBL
Ligand
BDBM50085041
(2-(4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propox...)
Copy SMILES
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Affinity Data
EC50: 1.00E+4nM
Assay Description:
Agonist activity for Human PPAR alpha receptor in transcriptional activation assay
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Target
Peroxisome proliferator-activated receptor delta
(Homo sapiens (Human))
Marquette University
Curated by
ChEMBL
Ligand
BDBM50085041
(2-(4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propox...)
Copy SMILES
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Affinity Data
EC50: 21nM
Assay Description:
Agonist activity at human GAL4-PPARdelta ligand binding domain expressed in human HepG2 cells by luciferase reporter gene assay
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Target
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human))
Glaxo Wellcome Research & Development
Curated by
ChEMBL
Ligand
BDBM50085041
(2-(4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propox...)
Copy SMILES
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Affinity Data
EC50: 977nM
Assay Description:
Activity at PPARalpha by luciferase reporter gene transactivation assay in COS7 cells
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Target
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human))
Université
Curated by
ChEMBL
Ligand
BDBM50085041
(2-(4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propox...)
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Affinity Data
EC50: 1.82E+3nM
Assay Description:
Activity at PPARgamma by luciferase reporter gene transactivation assay in COS7 cells
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Target
Peroxisome proliferator-activated receptor delta
(Homo sapiens (Human))
Marquette University
Curated by
ChEMBL
Ligand
BDBM50085041
(2-(4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propox...)
Copy SMILES
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Affinity Data
EC50: 125nM
Assay Description:
Activity at PPARbeta/delta by luciferase reporter gene transactivation assay in COS7 cells
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Target
Peroxisome proliferator-activated receptor delta
(Homo sapiens (Human))
Marquette University
Curated by
ChEMBL
Ligand
BDBM50085041
(2-(4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propox...)
Copy SMILES
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Affinity Data
EC50: 39nM
Assay Description:
Transactivation of human PPARdelta expressed in African green monkey COS7 cells incubated overnight by dual-glo luciferase reporter gene assay
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Target
Peroxisome proliferator-activated receptor delta
(Homo sapiens (Human))
Marquette University
Curated by
ChEMBL
Ligand
BDBM50085041
(2-(4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propox...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 650nM
Assay Description:
Transactivation of GAL4-fused PPARbeta (delta) ligand binding domain transfected in human HepG2 cells after 20 hrs by luciferase reporter gene assay
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Target
Peroxisome proliferator-activated receptor delta
(Homo sapiens (Human))
Marquette University
Curated by
ChEMBL
Ligand
BDBM50085041
(2-(4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propox...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 21nM
Assay Description:
Agonist activity at human GAL4-fused PPARdelta ligand binding domain expressed in COS-1 cells after 20 hrs by luciferase reporter gene transactivatio...
More data for this Ligand-Target Pair
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Target
Peroxisome proliferator-activated receptor delta
(Homo sapiens (Human))
Marquette University
Curated by
ChEMBL
Ligand
BDBM50085041
(2-(4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propox...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 39nM
Assay Description:
Transactivation of GAL4-fused human PPARdelta ligand binding domain transfected in african green monkey COS7 cells by luciferase reporter gene assay
More data for this Ligand-Target Pair
Target Info
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Target
Peroxisome proliferator-activated receptor delta
(Homo sapiens (Human))
Marquette University
Curated by
ChEMBL
Ligand
BDBM50085041
(2-(4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propox...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 640nM
Assay Description:
Transactivation of GAL4-fused PPARbeta LBD expressed in HepG2 cells after 20 hrs by luminescence assay
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Target
Peroxisome proliferator-activated receptor delta
(Homo sapiens (Human))
Marquette University
Curated by
ChEMBL
Ligand
BDBM50085041
(2-(4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propox...)
Copy SMILES
Copy InChI
Affinity Data
K
on
: 0.430M
-1
s
-1
Assay Description:
Binding affinity to PPARdelta (unknown origin) assessed as kinetic dissociation constant by SPR assay
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Target
Peroxisome proliferator-activated receptor delta
(Homo sapiens (Human))
Marquette University
Curated by
ChEMBL
Ligand
BDBM50085041
(2-(4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propox...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 20nM
Assay Description:
Inhibition of FTase-catalyzed incorporation of [3H]- FPP radioligand into recombinant Ha-Ras by 50% at an enzyme concentration of 1 nM.
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Target
Peroxisome proliferator-activated receptor delta
(Homo sapiens (Human))
Marquette University
Curated by
ChEMBL
Ligand
BDBM50085041
(2-(4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propox...)
Copy SMILES
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Affinity Data
Kd: 76nM
Assay Description:
Inhibition of FTase-catalyzed incorporation of [3H]- FPP radioligand into recombinant Ha-Ras by 50% at an enzyme concentration of 1 nM.
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Target
Peroxisome proliferator-activated receptor delta
(Homo sapiens (Human))
Marquette University
Curated by
ChEMBL
Ligand
BDBM50085041
(2-(4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propox...)
Copy SMILES
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Affinity Data
EC50: 61nM
Assay Description:
Agonist activity at PPARbeta (unknown origin) incubated for 3 to 16 hrs by pathhunter nuclear hormone receptor assay
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Target
Peroxisome proliferator-activated receptor delta
(Homo sapiens (Human))
Marquette University
Curated by
ChEMBL
Ligand
BDBM50085041
(2-(4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propox...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 210nM
Assay Description:
Transactivation of GAL4-tagged human PPARdelta LBD expressed in human HepG2 cells at 100 nM to 100 uM incubated for 20 to 22 hrs by luciferase report...
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Target
Peroxisome proliferator-activated receptor delta
(Homo sapiens (Human))
Marquette University
Curated by
ChEMBL
Ligand
BDBM50085041
(2-(4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propox...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 21nM
Assay Description:
Agonist activity at yeast Gal4-fused human PPARdelta transfected in human HepG2 cells assessed as transactivation by measuring beta-galactosidase act...
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Target
Peroxisome proliferator-activated receptor delta
(Homo sapiens (Human))
Marquette University
Curated by
ChEMBL
Ligand
BDBM50085041
(2-(4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propox...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 6nM
Assay Description:
Agonist activity at human PPAR-delta expressed in CHO-K1 cells by PathHunter assay
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Target
Fatty acid-binding protein, intestinal
(Homo sapiens (Human))
Monash University
Ligand
BDBM50085041
(2-(4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propox...)
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Affinity Data
Kd: 7.20E+3nM
pH: 8.0 T: 2°C
Assay Description:
ITC experiments were carried out using an iTC200 microcalorimeter (MicroCal) with coin shaped sample cell (200 μL) at 37 C with stirring at 1000...
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Target
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human))
Université
Curated by
ChEMBL
Ligand
BDBM50085041
(2-(4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propox...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 5.50E+3nM
Assay Description:
Agonist activity for Human PPAR gamma receptor in transcriptional activation assay
More data for this Ligand-Target Pair
Target Info
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