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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
21
hits in this display
Target
Cysteinyl leukotriene receptor 1
(GUINEA PIG)
Rorer Central Research
Curated by
ChEMBL
Ligand
BDBM50006812
(7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...)
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Affinity Data
Ki: 510nM
Assay Description:
Binding affinity against Cysteinyl leukotriene D4 receptor from guinea pig lung was determined using [3H]-LTD4 (0.2 nM)
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Target
Cysteinyl leukotriene receptor 1
(GUINEA PIG)
Rorer Central Research
Curated by
ChEMBL
Ligand
BDBM50006812
(7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...)
Copy SMILES
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Affinity Data
Ki: 510nM
Assay Description:
Binding affinity against LTD4 receptor in guinea pig lung membranes.
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Target
Cysteinyl leukotriene receptor 1
(GUINEA PIG)
Rorer Central Research
Curated by
ChEMBL
Ligand
BDBM50006812
(7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 800nM
Assay Description:
Compound was evaluated for its ability to displace [3H]-LTD4 from LTD4 receptor in guinea pig lung membranes
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Target
Cysteinyl leukotriene receptor 1
(GUINEA PIG)
Rorer Central Research
Curated by
ChEMBL
Ligand
BDBM50006812
(7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 940nM
Assay Description:
Binding affinity against Cysteinyl leukotriene D4 receptor from guinea pig lung was determined using [3H]-LTD4 (0.2 nM)
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Target
Cysteinyl leukotriene receptor 1/2
(Homo sapiens (Human))
Rorer Central Research
Curated by
ChEMBL
Ligand
BDBM50006812
(7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...)
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Affinity Data
Ki: 1.00E+3nM
Assay Description:
In vitro binding affinity against cysteinyl leukotriene D4 receptor from guinea pig lung membrane
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Target
Cysteinyl leukotriene receptor 1
(GUINEA PIG)
Rorer Central Research
Curated by
ChEMBL
Ligand
BDBM50006812
(7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...)
Copy SMILES
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Affinity Data
Ki: 1.20E+3nM
Assay Description:
Binding affinity against Cysteinyl leukotriene D4 receptor in guinea pig lung membranes using [3H]-LTD4 as the radioligand.
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Target
Cysteinyl leukotriene receptor 1/2
(Homo sapiens (Human))
Rorer Central Research
Curated by
ChEMBL
Ligand
BDBM50021024
(7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...)
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Affinity Data
Ki: 2.01E+3nM
Assay Description:
Compound is evaluated for its ability to inhibit [3H]LTD4 binding to Cysteinyl leukotriene D4 receptor in guinea pig lung membranes
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Target
Cysteinyl leukotriene receptor 1
(GUINEA PIG)
Rorer Central Research
Curated by
ChEMBL
Ligand
BDBM50021024
(7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...)
Copy SMILES
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Affinity Data
Ki: 2.20E+3nM
Assay Description:
Binding constant was determined as affinity to displace [3H]-LTD4 from Cysteinyl leukotriene D4 receptor on guinea pig lung membrane
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Target
Cysteinyl leukotriene receptor 1/2
(Homo sapiens (Human))
Rorer Central Research
Curated by
ChEMBL
Ligand
BDBM50006812
(7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...)
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Affinity Data
IC50: 35nM
Assay Description:
In vitro inhibition of SRS-A-induced contractions in guinea pig ileum
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Target
Cysteinyl leukotriene receptor 1/2
(Homo sapiens (Human))
Rorer Central Research
Curated by
ChEMBL
Ligand
BDBM50006812
(7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...)
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Affinity Data
IC50: 50nM
Assay Description:
Inhibition of LTD4-induced contraction in guinea pig ileum
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Target
Cysteinyl leukotriene receptor 1/2
(Homo sapiens (Human))
Rorer Central Research
Curated by
ChEMBL
Ligand
BDBM50021024
(7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...)
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Affinity Data
IC50: 100nM
Assay Description:
Inhibition of LTC4 induced smooth muscle contraction of guinea pig ileum
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Target
Cysteinyl leukotriene receptor 1/2
(Homo sapiens (Human))
Rorer Central Research
Curated by
ChEMBL
Ligand
BDBM50006812
(7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...)
Copy SMILES
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Affinity Data
IC50: 510nM
Assay Description:
Inhibition of the spasmogenic activity of LTD4 in guinea pig parenchymal strips.
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Target
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human))
Eisai
Curated by
ChEMBL
Ligand
BDBM50006812
(7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...)
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Affinity Data
IC50: 1.58E+3nM
Assay Description:
Inhibitory activity against cyclic GMP-phosphodiesterase (PDE V) isolated from porcine aorta.
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Target
Cysteinyl leukotriene receptor 1
(Homo sapiens (Human))
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM50006812
(7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...)
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Affinity Data
IC50: 4.00E+3nM
Assay Description:
Compound was tested for binding affinity against Cysteinyl leukotriene D4 receptor
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Target
Cysteinyl leukotriene receptor 1/2
(Homo sapiens (Human))
Rorer Central Research
Curated by
ChEMBL
Ligand
BDBM50006812
(7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...)
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Affinity Data
IC50: 4.00E+3nM
Assay Description:
Inhibitory activity to block binding of [3H]leukotriene D4 to LTD4 receptor sites in homogenized guinea pig lung
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Target
Thromboxane-A synthase
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50006812
(7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...)
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Affinity Data
IC50: 1.00E+4nM
Assay Description:
Inhibition of human platelet thromboxane synthase (TXA2) was determined in human platelets
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Target
Bile salt export pump
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50006812
(7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...)
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Affinity Data
IC50: <1.00E+4nM
Assay Description:
Ability to inhibit HMG-CoA reductase (HMGR) by CoA reductase inhibition screen (COR) in rats
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus)
Wyeth-Ayerst Research
Curated by
ChEMBL
Ligand
BDBM50006812
(7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...)
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Affinity Data
IC50: 2.10E+4nM
Assay Description:
The compound was tested for inhibitory activity against 5-lipoxygenase in rat RBL-1 cells
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Target
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
(BOVINE)
Roche Research Center
Curated by
ChEMBL
Ligand
BDBM50006812
(7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...)
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Affinity Data
IC50: 4.00E+4nM
Assay Description:
Inhibition of bovine heart Phosphodiesterase 1A
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Target
Cysteinyl leukotriene receptor 1
(GUINEA PIG)
Rorer Central Research
Curated by
ChEMBL
Ligand
BDBM50006812
(7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...)
Copy SMILES
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Affinity Data
Kd: 1.12E+3nM
Assay Description:
Dissociation constant was determined against Cysteinyl leukotriene D4 receptor of guinea pig lung membranes using radioligand binding assays.
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Target
Cysteinyl leukotriene receptor 1/2
(Homo sapiens (Human))
Rorer Central Research
Curated by
ChEMBL
Ligand
BDBM50006812
(7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydro...)
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Affinity Data
Kd: 1.12E+3nM
Assay Description:
Displacement of [3H]LTD4 from Cysteinyl leukotriene D4 receptor in guinea pig lung membranes
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