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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
4
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Target
N-lysine methyltransferase SMYD2
(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft
US Patent
Ligand
BDBM283166
(N-[1-(N′-cyano-N-{3-[2-(dimethylamino)ethoxy...)
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Affinity Data
IC50: 159nM
pH: 9.0
Assay Description:
SMYD2 inhibitory activities of the compounds described in the present invention were quantified using a scintillation proximity assay (SPA) which mea...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
N-lysine methyltransferase SMYD2
(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft
US Patent
Ligand
BDBM283165
(Rac-N-[1-(N′-cyano-N-{3-[2-(dimethylamino)et...)
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Affinity Data
IC50: 358nM
pH: 9.0
Assay Description:
SMYD2 inhibitory activities of the compounds described in the present invention were quantified using a scintillation proximity assay (SPA) which mea...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
N-lysine methyltransferase SMYD2
(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft
US Patent
Ligand
BDBM283166
(N-[1-(N′-cyano-N-{3-[2-(dimethylamino)ethoxy...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.58E+3nM
Assay Description:
For the detection of SMYD2 cellular methylation activity an In Cell Western (ICW) assay was established. This assay allows rapid processing of multip...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
N-lysine methyltransferase SMYD2
(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft
US Patent
Ligand
BDBM283166
(N-[1-(N′-cyano-N-{3-[2-(dimethylamino)ethoxy...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.79E+3nM
pH: 9.0
Assay Description:
SMYD2 inhibitory activities of the compounds described in the present invention were quantified using a scintillation proximity assay (SPA) which mea...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI