Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 33 hits in this display   

TargetMuscarinic acetylcholine receptor(RABBIT)
Glaxo Group Research

Curated by PDSP Ki Database
LigandPNGBDBM50151858(4-(diethylamino)but-2-yn-1-yl (2S)-cyclohexyl(hydr...)
Affinity DataKi:  0.450nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMuscarinic acetylcholine receptor M3(RAT)
Glaxo Group Research

Curated by PDSP Ki Database
LigandPNGBDBM50151858(4-(diethylamino)but-2-yn-1-yl (2S)-cyclohexyl(hydr...)
Affinity DataKi:  0.630nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Glaxo Group Research

Curated by PDSP Ki Database
LigandPNGBDBM50151858(4-(diethylamino)but-2-yn-1-yl (2S)-cyclohexyl(hydr...)
Affinity DataKi:  0.650nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50165019(4-(Diethylamino)-2-butynyl alpha-phenylcyclohexane...)
Affinity DataKi:  0.780nMAssay Description:Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M3 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMuscarinic acetylcholine receptor M3(RAT)
Glaxo Group Research

Curated by PDSP Ki Database
LigandPNGBDBM50165019(4-(Diethylamino)-2-butynyl alpha-phenylcyclohexane...)
Affinity DataKi:  0.950nMAssay Description:Affinity for rat Muscarinic acetylcholine receptor M3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50165019(4-(Diethylamino)-2-butynyl alpha-phenylcyclohexane...)
Affinity DataKi:  1nMAssay Description:Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M1 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50165019(4-(Diethylamino)-2-butynyl alpha-phenylcyclohexane...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to human muscarinic M3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50165019(4-(Diethylamino)-2-butynyl alpha-phenylcyclohexane...)
Affinity DataKi:  1.51nMAssay Description:Displacement of [3H]N-methylscopolamine from human muscarinic M3 receptor expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50165019(4-(Diethylamino)-2-butynyl alpha-phenylcyclohexane...)
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]N-methylscopolamine from human muscarinic M1 receptor expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(Chick)
Glaxo Group Research

Curated by PDSP Ki Database
LigandPNGBDBM50151858(4-(diethylamino)but-2-yn-1-yl (2S)-cyclohexyl(hydr...)
Affinity DataKi:  2.69nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Glaxo Group Research

Curated by PDSP Ki Database
LigandPNGBDBM50151858(4-(diethylamino)but-2-yn-1-yl (2S)-cyclohexyl(hydr...)
Affinity DataKi:  3.16nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50165019(4-(Diethylamino)-2-butynyl alpha-phenylcyclohexane...)
Affinity DataKi:  3.63nMAssay Description:Displacement of [3H]N-methylscopolamine from human muscarinic M4 receptor expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(RAT)
Glaxo Group Research

Curated by PDSP Ki Database
LigandPNGBDBM50165019(4-(Diethylamino)-2-butynyl alpha-phenylcyclohexane...)
Affinity DataKi:  5.30nMAssay Description:Binding affinity for rat salivary gland muscarinic acetylcholine receptor M3 using [3H]N-methylscopolamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Glaxo Group Research

Curated by PDSP Ki Database
LigandPNGBDBM50165019(4-(Diethylamino)-2-butynyl alpha-phenylcyclohexane...)
Affinity DataKi:  5.90nMAssay Description:Binding affinity for rat cortex muscarinic acetylcholine receptor M1 using [3H]pirenzepineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Glaxo Group Research

Curated by PDSP Ki Database
LigandPNGBDBM50165019(4-(Diethylamino)-2-butynyl alpha-phenylcyclohexane...)
Affinity DataKi:  6.97nMAssay Description:Affinity for rat Muscarinic acetylcholine receptor M2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50165019(4-(Diethylamino)-2-butynyl alpha-phenylcyclohexane...)
Affinity DataKi:  8.10nMAssay Description:Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50165019(4-(Diethylamino)-2-butynyl alpha-phenylcyclohexane...)
Affinity DataKi:  11.8nMAssay Description:Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Glaxo Group Research

Curated by PDSP Ki Database
LigandPNGBDBM50165019(4-(Diethylamino)-2-butynyl alpha-phenylcyclohexane...)
Affinity DataKi:  14nMAssay Description:Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50165019(4-(Diethylamino)-2-butynyl alpha-phenylcyclohexane...)
Affinity DataKi:  14.1nMAssay Description:Displacement of [3H]N-methylscopolamine from human muscarinic M5 receptor expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50165019(4-(Diethylamino)-2-butynyl alpha-phenylcyclohexane...)
Affinity DataKi:  16nMAssay Description:Binding affinity to human muscarinic M2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50151858(4-(diethylamino)but-2-yn-1-yl (2S)-cyclohexyl(hydr...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibitory concentration against IKr potassium channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Cavia porcellus)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50165019(4-(Diethylamino)-2-butynyl alpha-phenylcyclohexane...)
Affinity DataIC50:  1.61E+4nMAssay Description:Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50165019(4-(Diethylamino)-2-butynyl alpha-phenylcyclohexane...)
Affinity DataIC50:  2.74E+4nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50165019(4-(Diethylamino)-2-butynyl alpha-phenylcyclohexane...)
Affinity DataIC50:  2.74E+4nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50165019(4-(Diethylamino)-2-butynyl alpha-phenylcyclohexane...)
Affinity DataIC50:  2.74E+4nMAssay Description:Inhibition of recombinant human BSEP expressed in baculovirus infected sf9 cell plasma membrane vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal(3)malignant brain tumor-like protein 3(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50165019(4-(Diethylamino)-2-butynyl alpha-phenylcyclohexane...)
Affinity DataIC50: >5.40E+4nMAssay Description:Inhibition of L3MBTL3 by alpha-screeningMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal(3)malignant brain tumor-like protein 4(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50165019(4-(Diethylamino)-2-butynyl alpha-phenylcyclohexane...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of L3MBTL4 by alpha-screeningMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoform 4 of Lethal(3)malignant brain tumor-like protein 1 (4)(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50165019(4-(Diethylamino)-2-butynyl alpha-phenylcyclohexane...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of L3MBTL1 by alpha-screeningMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMBT domain-containing protein 1(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50165019(4-(Diethylamino)-2-butynyl alpha-phenylcyclohexane...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of MBTD1 by alpha-screeningMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50165019(4-(Diethylamino)-2-butynyl alpha-phenylcyclohexane...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50165019(4-(Diethylamino)-2-butynyl alpha-phenylcyclohexane...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50165019(4-(Diethylamino)-2-butynyl alpha-phenylcyclohexane...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor(Cavia porcellus)
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50151858(4-(diethylamino)but-2-yn-1-yl (2S)-cyclohexyl(hydr...)
Affinity DataKd:  79nMAssay Description:Antagonism in muscarinic M3 receptor in guinea pig left atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed