Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 6 hits in this display   

TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312243(1-{4-Chloro-2-[(ethylamino)methyl]benzyl}-2-thioxo...)
Affinity DataIC50:  22nMAssay Description:The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the pres...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312243(1-{4-Chloro-2-[(ethylamino)methyl]benzyl}-2-thioxo...)
Affinity DataIC50:  22nMAssay Description:MPO: The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312243(1-{4-Chloro-2-[(ethylamino)methyl]benzyl}-2-thioxo...)
Affinity DataIC50:  22nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyroid peroxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312243(1-{4-Chloro-2-[(ethylamino)methyl]benzyl}-2-thioxo...)
Affinity DataIC50:  1.00E+4nMAssay Description:MPO: The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyroid peroxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312243(1-{4-Chloro-2-[(ethylamino)methyl]benzyl}-2-thioxo...)
Affinity DataIC50:  1.00E+4nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyroid peroxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312243(1-{4-Chloro-2-[(ethylamino)methyl]benzyl}-2-thioxo...)
Affinity DataIC50:  1.00E+4nMAssay Description:To detect thyroid peroxidase (TPO) inhibitory activity, the production of hypoiodous acid (HOI) was quantified. HOI was detected by reacting it with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent