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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
6
hits in this display
Target
Myeloperoxidase
(Homo sapiens (Human))
Astrazeneca
US Patent
Ligand
BDBM312243
(1-{4-Chloro-2-[(ethylamino)methyl]benzyl}-2-thioxo...)
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Affinity Data
IC50: 22nM
Assay Description:
The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the pres...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Myeloperoxidase
(Homo sapiens (Human))
Astrazeneca
US Patent
Ligand
BDBM312243
(1-{4-Chloro-2-[(ethylamino)methyl]benzyl}-2-thioxo...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 22nM
Assay Description:
MPO: The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Myeloperoxidase
(Homo sapiens (Human))
Astrazeneca
US Patent
Ligand
BDBM312243
(1-{4-Chloro-2-[(ethylamino)methyl]benzyl}-2-thioxo...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 22nM
Assay Description:
Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Thyroid peroxidase
(Homo sapiens (Human))
Astrazeneca
US Patent
Ligand
BDBM312243
(1-{4-Chloro-2-[(ethylamino)methyl]benzyl}-2-thioxo...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.00E+4nM
Assay Description:
MPO: The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the...
More data for this Ligand-Target Pair
Target Info
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Thyroid peroxidase
(Homo sapiens (Human))
Astrazeneca
US Patent
Ligand
BDBM312243
(1-{4-Chloro-2-[(ethylamino)methyl]benzyl}-2-thioxo...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.00E+4nM
Assay Description:
Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...
More data for this Ligand-Target Pair
Target Info
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Thyroid peroxidase
(Homo sapiens (Human))
Astrazeneca
US Patent
Ligand
BDBM312243
(1-{4-Chloro-2-[(ethylamino)methyl]benzyl}-2-thioxo...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.00E+4nM
Assay Description:
To detect thyroid peroxidase (TPO) inhibitory activity, the production of hypoiodous acid (HOI) was quantified. HOI was detected by reacting it with ...
More data for this Ligand-Target Pair
Target Info
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI