Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 23 hits in this display   

LigandPNGBDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataKi:  0.210nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataKi:  0.25nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel dihydropyridine site of porcine cardiac sarcolemma membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataKi:  0.350nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataKi:  1.76nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataKi:  80.1nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataKi:  8.30E+3nMAssay Description:Displacement of [125]AB-MECA binding to human Adenosine A3 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataKi:  8.96E+3nMAssay Description:Displacement of [3H](R)-PIA binding to Adenosine A1 receptor in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataKi:  2.30E+4nMAssay Description:Displacement of [3H]-CGS- 21680 binding to Adenosine A2A receptor in rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Cavia porcellus)
Alter

Curated by ChEMBL
LigandPNGBDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataKi:  7.33E+4nMAssay Description:Tested for inhibition of [3H]PAF binding to rabbit platelet Platelet activating factor receptor More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1F/alpha-1S(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataIC50:  0.150nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel of guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1F/alpha-1S(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of voltage-gated L-type Ca channel (species unknown)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1F/alpha-1S(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataIC50:  1nMAssay Description:In vitro vasorelaxant activity (calcium channel blocking activity) was determined with potassium-depolarized rabbit thoracic aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 55(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataIC50:  1.47E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of hERG K channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human Potassium channel HERG expressed in mammalian cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibitory concentration against potassium channel HERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 7 subunit alpha(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataIC50:  3.60E+4nMAssay Description:Inhibition of Na channel (species unknown)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataIC50:  3.60E+4nMAssay Description:Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataIC50:  1.00E+6nMAssay Description:Inhibition of Thromboxane A2 synthase after oral administration of 0.03 mmol/kgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Mus musculus)
Ferrara University

Curated by ChEMBL
LigandPNGBDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataEC50:  3.80E+3nMAssay Description:Agonist activity at mouse TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataKd:  0.260nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel in guinea pig ventricular myocardium membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed