Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 2 hits in this display   

TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandBDBM24716(Tetrahydropyrazolo[3,4-a]carbazole, 25 | ethyl 3,4...)Copy SMILESCopy InChI

Affinity DataIC50:  5.70E+3nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetMitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL

LigandBDBM24716(Tetrahydropyrazolo[3,4-a]carbazole, 25 | ethyl 3,4...)Copy SMILESCopy InChI

Affinity DataEC50:  4.86E+3nMAssay Description:Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosisMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI