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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
3
hits in this display
Target
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50328389
(CHEMBL1257330 | ethyl 7-(2-hydroxyethyl)-2-morphol...)
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Affinity Data
IC50: 180nM
Assay Description:
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50328389
(CHEMBL1257330 | ethyl 7-(2-hydroxyethyl)-2-morphol...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 260nM
Assay Description:
Inhibition of DGAT1 in human Caco2 cells after 30 mins
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Sterol O-acyltransferase 1
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50328389
(CHEMBL1257330 | ethyl 7-(2-hydroxyethyl)-2-morphol...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.05E+3nM
Assay Description:
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI