Home
About
Info
Download
WebServices
Contact
Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
7
hits in this display
Target
Mitogen-activated protein kinase 8
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM15913
(2-pyridinecarboxamide deriv. 8c | 4-Amino-5-cyano-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.70nM
Assay Description:
Inhibition of JNK1-mediated ATF2 phosphorylation after 1 hr by ELISA
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Mitogen-activated protein kinase 8
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM15913
(2-pyridinecarboxamide deriv. 8c | 4-Amino-5-cyano-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 19nM
pH: 7.2 T: 2°C
Assay Description:
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Mitogen-activated protein kinase 8
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM15913
(2-pyridinecarboxamide deriv. 8c | 4-Amino-5-cyano-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 19nM
Assay Description:
Inhibition of JNK1
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Mitogen-activated protein kinase 9
(Homo sapiens (Human))
Abbott Laboratories
Ligand
BDBM15913
(2-pyridinecarboxamide deriv. 8c | 4-Amino-5-cyano-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 120nM
Assay Description:
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Mitogen-activated protein kinase 9
(Homo sapiens (Human))
Abbott Laboratories
Ligand
BDBM15913
(2-pyridinecarboxamide deriv. 8c | 4-Amino-5-cyano-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 120nM
Assay Description:
Inhibition of JNK2
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
40S ribosomal protein S27
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM15913
(2-pyridinecarboxamide deriv. 8c | 4-Amino-5-cyano-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 568nM
Assay Description:
Inhibition of Mps1-mediated p38 MAPK phosphorylation after 90 mins by DELFIA assay
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Transcription factor Jun
(Homo sapiens (Human))
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM15913
(2-pyridinecarboxamide deriv. 8c | 4-Amino-5-cyano-...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 318nM
Assay Description:
Inhibition of c-Jun phosphorylation in HepG2 cells
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI