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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
19
hits in this display
Target
Aurora kinase B
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50273571
(CHEMBL514409 | Hesperadin | N-(2-oxo-3-(phenyl(4-(...)
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Affinity Data
IC50: 3nM
Assay Description:
Inhibition of human Aurora kinase B/INCEP complex expressed in Escherichia coli BL21 (DE3) using gamma-[32P]ATP incubated for 1 hr by autoradiography
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
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ChEBI
CHEMBL
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Target
Aurora kinase B-A
(Xenopus laevis)
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50273571
(CHEMBL514409 | Hesperadin | N-(2-oxo-3-(phenyl(4-(...)
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Affinity Data
IC50: 3nM
Assay Description:
Inhibition of Xenopus laevis Aurora kinase B/INCEP complex using gamma-[32P]ATP incubated for 1 hr by autoradiography
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
ChEBI
CHEMBL
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PC sid
PDB
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In Depth
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Article
PubMed
PDB
3D Structure (crystal)
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Target
Aurora kinase A
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50273571
(CHEMBL514409 | Hesperadin | N-(2-oxo-3-(phenyl(4-(...)
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Affinity Data
IC50: 11nM
Assay Description:
Inhibition of human Aurora kinase A/TPX2 complex using gamma-[32P]ATP incubated for 1 hr by autoradiography
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
ChEBI
CHEMBL
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Article
PubMed
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Target
Maternal embryonic leucine zipper kinase
(Homo sapiens (Human))
The University Of Texas At Austin
Curated by
ChEMBL
Ligand
BDBM50273571
(CHEMBL514409 | Hesperadin | N-(2-oxo-3-(phenyl(4-(...)
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Affinity Data
IC50: 225nM
Assay Description:
Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as s...
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
ChEBI
CHEMBL
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In Depth
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Target
Aurora kinase B
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50273571
(CHEMBL514409 | Hesperadin | N-(2-oxo-3-(phenyl(4-(...)
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Affinity Data
IC50: 250nM
Assay Description:
Inhibition of Aurora-B immunoprecipitated from mitotic cells
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
ChEBI
CHEMBL
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PC sid
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In Depth
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Article
PubMed
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Target
Aurora kinase B
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50273571
(CHEMBL514409 | Hesperadin | N-(2-oxo-3-(phenyl(4-(...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 250nM
Assay Description:
Inhibition of recombinant human full-length His-tagged Aurora B expressed in baculovirus expression system using 5-FAM-LRRASLG-CONH2 as substrate pre...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
ChEBI
CHEMBL
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PC sid
PDB
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In Depth
Details
Article
PubMed
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Target
Aurora kinase B
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50273571
(CHEMBL514409 | Hesperadin | N-(2-oxo-3-(phenyl(4-(...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 250nM
Assay Description:
Inhibition of aurora B kinase (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
Ligand Info
ChEBI
CHEMBL
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PC sid
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In Depth
Details
PubMed
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Target
Aurora kinase B
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50273571
(CHEMBL514409 | Hesperadin | N-(2-oxo-3-(phenyl(4-(...)
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Copy InChI
Affinity Data
IC50: 250nM
Assay Description:
Inhibition of aurora B kinase
Checked by Author
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
ChEBI
CHEMBL
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PC sid
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In Depth
Details
Article
PubMed
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Target
Ribosomal protein S6 kinase alpha-4
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50273571
(CHEMBL514409 | Hesperadin | N-(2-oxo-3-(phenyl(4-(...)
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Affinity Data
Kd: 94nM
Assay Description:
Binding affinity to human MSK2
More data for this Ligand-Target Pair
Target Info
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
ChEBI
CHEMBL
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PC sid
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PubMed
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Target
5'-AMP-activated protein kinase catalytic subunit alpha-1
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50273571
(CHEMBL514409 | Hesperadin | N-(2-oxo-3-(phenyl(4-(...)
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Affinity Data
Kd: 19nM
Assay Description:
Binding affinity to human AMPKA1
More data for this Ligand-Target Pair
Target Info
PDB
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ChEBI
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Target
Serine/threonine-protein kinase BRSK2
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50273571
(CHEMBL514409 | Hesperadin | N-(2-oxo-3-(phenyl(4-(...)
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Affinity Data
Kd: 92nM
Assay Description:
Binding affinity to human BRSK2
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
ChEBI
CHEMBL
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PC sid
PDB
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In Depth
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Article
PubMed
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Target
Serine/threonine-protein kinase PAK 2
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50273571
(CHEMBL514409 | Hesperadin | N-(2-oxo-3-(phenyl(4-(...)
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Affinity Data
Kd: 1.40E+4nM
Assay Description:
Binding affinity to human PAK2
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
ChEBI
CHEMBL
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PC sid
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In Depth
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Article
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Target
Tyrosine-protein kinase Fes/Fps
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50273571
(CHEMBL514409 | Hesperadin | N-(2-oxo-3-(phenyl(4-(...)
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Affinity Data
Kd: 149nM
Assay Description:
Binding affinity to human FES
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
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Ligand Info
ChEBI
CHEMBL
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PC sid
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In Depth
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Article
PubMed
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Target
Protein-tyrosine kinase 2-beta
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50273571
(CHEMBL514409 | Hesperadin | N-(2-oxo-3-(phenyl(4-(...)
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Affinity Data
Kd: 10nM
Assay Description:
Binding affinity to human PYK2
More data for this Ligand-Target Pair
Target Info
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UniProtKB/SwissProt
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Ligand Info
ChEBI
CHEMBL
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PC sid
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In Depth
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Article
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Target
Proto-oncogene tyrosine-protein kinase ROS
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50273571
(CHEMBL514409 | Hesperadin | N-(2-oxo-3-(phenyl(4-(...)
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Affinity Data
Kd: 77nM
Assay Description:
Binding affinity to human ROS
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
ChEBI
CHEMBL
PC cid
PC sid
PDB
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In Depth
Details
Article
PubMed
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Target
Leukocyte tyrosine kinase receptor
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50273571
(CHEMBL514409 | Hesperadin | N-(2-oxo-3-(phenyl(4-(...)
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Affinity Data
Kd: 52nM
Assay Description:
Binding affinity to human LTK
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
ChEBI
CHEMBL
PC cid
PC sid
PDB
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In Depth
Details
Article
PubMed
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Target
Ribosomal protein S6 kinase alpha-5
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50273571
(CHEMBL514409 | Hesperadin | N-(2-oxo-3-(phenyl(4-(...)
Copy SMILES
Copy InChI
Affinity Data
Kd: 31nM
Assay Description:
Binding affinity to human MSK1
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
ChEBI
CHEMBL
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
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Target
Non-receptor tyrosine-protein kinase TYK2
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50273571
(CHEMBL514409 | Hesperadin | N-(2-oxo-3-(phenyl(4-(...)
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Affinity Data
Kd: 75nM
Assay Description:
Binding affinity to human TYK2
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
ChEBI
CHEMBL
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Focal adhesion kinase 1
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50273571
(CHEMBL514409 | Hesperadin | N-(2-oxo-3-(phenyl(4-(...)
Copy SMILES
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Affinity Data
Kd: 33nM
Assay Description:
Binding affinity to human FAK
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
ChEBI
CHEMBL
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI