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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 20 hits in this display   

TargetThiosulfate sulfurtransferase(Homo sapiens)
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50105463(2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...)
Affinity DataIC50:  830nMAssay Description:Inhibition of native rhodanese (unknown origin) assessed as reduction in rhodanese enzyme activity after 45 mins by Fe(SCN)3 dye based spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
University Of Missouri

Curated by ChEMBL
LigandPNGBDBM50105463(2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of HIV-1 reverse transcriptase using Poly(rA).p(dT) (12 to 18) as substrate after 30 mins by single point PCR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50105463(2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of telomerase in human MGC803 cells after 24 hrs by TRAP-PCR-ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50105463(2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of telomerase in human MGC803 cell extracts after 24 hrs by TRAP-PCR-ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50105463(2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...)
Affinity DataIC50:  2.18E+3nMAssay Description:Inhibition of telomerase in human MGC803 cells after 24 hrs by TRAP-PCR-ELISA methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50105463(2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...)
Affinity DataIC50:  2.33E+3nMAssay Description:Inhibition of telomerase in human MDA-MB-231 cells after 24 hrs by TRAP-PCR-ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50105463(2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...)
Affinity DataIC50:  2.39E+3nMAssay Description:Inhibition of telomerase-mediated supercoiling activity in human MGC803 cells after 24 hrs by TRAP-PCR-ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCo-chaperonin GroES(Escherichia coli)
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50105463(2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50105463(2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...)
Affinity DataIC50:  2.47E+3nMAssay Description:Inhibition of telomerase supercoiling activity in human MGC803 cells after 24 hrs by TRAP-PCR-ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50105463(2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of telomerase in human SGC7901 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50105463(2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of telomerase in human SGC7901 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50105463(2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of telomerase in human SGC7901 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50105463(2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of telomerase activity expressed in human SGC7901 cells by SYBER green dye based TRAPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50105463(2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibitory activity of the compound against telomerase (Compound released from RNA/DNA heteroduplex derivatized resin [sequence (TTAGGG)3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50105463(2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibitory activity of the compound against telomerase (Compound released from underivatized resinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50105463(2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibitory activity of the compound against telomerase (Compound released from DNA/DNA heteroduplex derivatized resin [sequence (TTAGGG)3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target60 kDa heat shock protein, mitochondrial(Homo sapiens)
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50105463(2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human N-terminal octa-His-tagged HSP60 expressed in Escherichia coli Rosetta(DE3) pLysS/human HSP10 expressed in Escherichia coli Roset...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCo-chaperonin GroES(Escherichia coli)
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50105463(2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Escherichia coli GroEL expressed in Escherichia coliDH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChaperonin GroEL(Escherichia coli)
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50105463(2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of ATPase activity of Escherichia coli GroEL expressed in Escherichia coliDH5alpha incubated for 60 mins using ATP by spectrometric analys...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance protein MdtK(Escherichia coli (strain K12))
Iowa State University

Curated by ChEMBL
LigandPNGBDBM50105463(2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...)
Affinity DataKd:  9.80E+3nMAssay Description:Binding affinity to Escherichia coli K-12 multidrug efflux protein YdhE expressed in Escherichia coli AG100AX in presence of 0.02% DDM surfactant by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed