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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
6
hits in this display
Target
Nociceptin receptor
(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50083232
(1-(1-Cyclooctylmethyl-piperidin-4-yl)-3-ethyl-1,3-...)
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Affinity Data
IC50: 6.80nM
Assay Description:
Inhibition of [125I]-Tyr14-nociceptin binding to human Opioid receptor like 1 (opioid receptor like 1) in CHO cells
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
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Target
Nociceptin receptor
(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50083232
(1-(1-Cyclooctylmethyl-piperidin-4-yl)-3-ethyl-1,3-...)
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Copy InChI
Affinity Data
IC50: 20nM
Assay Description:
Antagonistic activity of the compound measured by GTPgammaS binding against Opioid receptor like 1 in CHO cells
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Kappa-type opioid receptor
(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50083232
(1-(1-Cyclooctylmethyl-piperidin-4-yl)-3-ethyl-1,3-...)
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Affinity Data
IC50: 440nM
Assay Description:
Binding affinity in CHO cells stably expressing cloned human Opioid receptor kappa 1 by displacing radioligand [3H]U-69593
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Mu-type opioid receptor
(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50083232
(1-(1-Cyclooctylmethyl-piperidin-4-yl)-3-ethyl-1,3-...)
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Affinity Data
IC50: 950nM
Assay Description:
Inhibition of [3H]-diprenorphine binding to human Opioid receptor mu 1 in CHO cells
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Delta-type opioid receptor
(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50083232
(1-(1-Cyclooctylmethyl-piperidin-4-yl)-3-ethyl-1,3-...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of [3H][D-Ala2,D-Leu5]enkephalin binding to human Opioid receptor delta 1 in CHO cells
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Nociceptin receptor
(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50083232
(1-(1-Cyclooctylmethyl-piperidin-4-yl)-3-ethyl-1,3-...)
Copy SMILES
Copy InChI
Affinity Data
EC50: >1.00E+4nM
Assay Description:
Agonistic activity of the compound measured by GTPgammaS binding against Opioid receptor like 1 in CHO cells
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI