Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

TargetNon-specific protein-tyrosine kinase(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50328199(1-ethyl-N-(4-(trifluoromethoxy)phenyl)-1H-pyrazolo...)
Affinity DataIC50:  300nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNon-specific protein-tyrosine kinase [T818I](Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50328199(1-ethyl-N-(4-(trifluoromethoxy)phenyl)-1H-pyrazolo...)
Affinity DataIC50:  7.30E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50328199(1-ethyl-N-(4-(trifluoromethoxy)phenyl)-1H-pyrazolo...)
Affinity DataEC50:  300nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed