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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 6 hits in this display   

TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM24089((5S)-5-(3-aminopropyl)-3-(2,5-difluorophenyl)-N,N-...)
Affinity DataIC50:  1.90nMpH: 7.0 T: 2°CAssay Description:The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM24089((5S)-5-(3-aminopropyl)-3-(2,5-difluorophenyl)-N,N-...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of KSPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM24089((5S)-5-(3-aminopropyl)-3-(2,5-difluorophenyl)-N,N-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of KSP by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM24084(3,5-diaryl-4,5-dihydropyrazole, 10a | 5-(3-aminopr...)
Affinity DataIC50:  8nMpH: 7.0 T: 2°CAssay Description:The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM24089((5S)-5-(3-aminopropyl)-3-(2,5-difluorophenyl)-N,N-...)
Affinity DataIC50:  19.3nMpH: 7.4 T: 2°CAssay Description:The hERG IC50 values were determined by radioligand competition experiments using membrane preparations from human embryonic kidney cells that stably...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM24089((5S)-5-(3-aminopropyl)-3-(2,5-difluorophenyl)-N,N-...)
Affinity DataIC50:  1.93E+4nMAssay Description:Inhibition of hERG expressed in CHO cells by cell voltage clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed