Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 49 hits in this display   

Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataKi:  4.70nMAssay Description:The binding affinities shown in table 5 of psilocin and compound 8 at various monoaminergic receptors were determined in radioligand competition bind...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataKi:  12nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataKi:  19nMAssay Description:The binding affinities shown in table 5 of psilocin and compound 8 at various monoaminergic receptors were determined in radioligand competition bind...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataKi:  20nMAssay Description:The binding affinities shown in table 5 of psilocin and compound 8 at various monoaminergic receptors were determined in radioligand competition bind...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataKi:  25nMAssay Description:In vitro binding to 5-hydroxytryptamine 2A receptor using [125 I]-DOIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1E(Homo sapiens (Human))
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataKi:  44nMAssay Description:The binding affinities shown in table 5 of psilocin and compound 8 at various monoaminergic receptors were determined in radioligand competition bind...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataKi:  63nMAssay Description:The binding affinities shown in table 5 of psilocin and compound 8 at various monoaminergic receptors were determined in radioligand competition bind...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 5A(Homo sapiens (Human))
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataKi:  70nMAssay Description:The binding affinities shown in table 5 of psilocin and compound 8 at various monoaminergic receptors were determined in radioligand competition bind...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataKi:  72nMAssay Description:The binding affinities shown in table 5 of psilocin and compound 8 at various monoaminergic receptors were determined in radioligand competition bind...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataKi:  72nMAssay Description:The binding affinities shown in table 5 of psilocin and compound 8 at various monoaminergic receptors were determined in radioligand competition bind...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(3) dopamine receptor(Homo sapiens)
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataKi:  100nMAssay Description:The binding affinities shown in table 5 of psilocin and compound 8 at various monoaminergic receptors were determined in radioligand competition bind...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataKi:  140nMAssay Description:The binding affinities shown in table 5 of psilocin and compound 8 at various monoaminergic receptors were determined in radioligand competition bind...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataKi:  305nMAssay Description:The binding affinities shown in table 5 of psilocin and compound 8 at various monoaminergic receptors were determined in radioligand competition bind...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataKi:  323nMAssay Description:Displacement of [3H]MDL100907 from 5HT2A receptor in Sprague-Dawley rat brain by liquid scintillation spectroscopyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataKi:  340nMAssay Description:The binding affinities shown in table 5 of psilocin and compound 8 at various monoaminergic receptors were determined in radioligand competition bind...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataKi:  390nMAssay Description:Compound was tested for binding affinity using [3H]-MDL-100,907 at 5-hydroxytryptamine 2A receptor sites in rat cortical homogenate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(BOVINE)
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataKi:  450nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataKi:  1.30E+3nMAssay Description:The binding affinities shown in table 5 of psilocin and compound 8 at various monoaminergic receptors were determined in radioligand competition bind...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataKi:  2.00E+3nMAssay Description:The binding affinities shown in table 5 of psilocin and compound 8 at various monoaminergic receptors were determined in radioligand competition bind...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataKi: >1.00E+4nMAssay Description:The binding affinities shown in table 5 of psilocin and compound 8 at various monoaminergic receptors were determined in radioligand competition bind...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(4) dopamine receptor(Homo sapiens (Human))
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataKi: >1.00E+4nMAssay Description:The binding affinities shown in table 5 of psilocin and compound 8 at various monoaminergic receptors were determined in radioligand competition bind...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(1B) dopamine receptor(Homo sapiens (Human))
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataKi: >1.00E+4nMAssay Description:The binding affinities shown in table 5 of psilocin and compound 8 at various monoaminergic receptors were determined in radioligand competition bind...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A1(Homo sapiens (Human))
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataKi: >1.00E+4nMAssay Description:The binding affinities shown in table 5 of psilocin and compound 8 at various monoaminergic receptors were determined in radioligand competition bind...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A1 Isoform 2(Homo sapiens (Human))
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataKi: >1.00E+4nMAssay Description:The binding affinities shown in table 5 of psilocin and compound 8 at various monoaminergic receptors were determined in radioligand competition bind...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataIC50:  1.10nMAssay Description:Modulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataIC50:  7.80nMAssay Description:Modulation of human 5HT2C expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq f...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataIC50:  8.30nMAssay Description:Modulation of human 5HT2A expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataIC50:  112nMAssay Description:1. Culture the cells in cell culture medium (DMEM containing 10% FBS 1× penicillin-streptomycin 300 μg/ml G418 and 100 μg/ml hygromycin B) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataIC50:  352nMAssay Description:1. Culture the cells in cell culture medium (DMEM containing 10% FBS 1× penicillin-streptomycin 300 μg/ml G418 and 100 μg/ml hygromycin B) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataIC50: <500nMMore data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataIC50: <500nMAssay Description:Table 2: i. Prepare the assay buffer following the table below;Reagent ConcentrationTris 50 mMCaCl2  4 mMBSA 0.1% (w/v)Adjust pH to 7.4 followe...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataIC50: <500nMAssay Description:Table 2: i. Prepare the assay buffer following the table below;Reagent ConcentrationTris 50 mMCaCl2  4 mMBSA 0.1% (w/v)Adjust pH to 7.4 followe...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataIC50: <500nMAssay Description:i. Prepare the assay buffer following the table below;Reagent ConcentrationTris 50 mMCaCl2  4 mMBSA 0.1% (w/v)Adjust pH to 7.4 followed by 0.2 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataIC50: <500nMMore data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataEC50: <1.00E+3nMAssay Description:Agonist activity at human 5-HT2A receptor assessed as activation of calcium mobilization incubated for 2 mins by Calcium-6 dye based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataEC50:  2.30E+3nMAssay Description:Tested for its ability to activate phospholipase C by quantification of IP3 at cloned rat 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataEC50:  24nMAssay Description:Effective concentration required for accumulation of [3H]-inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataEC50:  58nMAssay Description:Effective concentration required for accumulation of [3H]-inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataEC50:  30nMAssay Description:Effective concentration required for accumulation of [3H]-inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determi...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataEC50:  4.30nMAssay Description:Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataEC50:  4.30nMAssay Description:Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Mus musculus (Mouse))
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataEC50:  9.90nMAssay Description:Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Mus musculus (Mouse))
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataEC50:  9.80nMAssay Description:Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataEC50:  6.5nMAssay Description:Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataEC50:  75nMAssay Description:Displacement of [3H]-ketanserin from human 5-HT2A receptor incubated for 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataEC50:  75nMAssay Description:Displacement of [3H]-ketanserin from human 5-HT2A receptor incubated for 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataEC50:  6.5nMAssay Description:Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataEC50: <1.00E+3nMAssay Description:Agonist activity at human 5-HT2A receptor expressed in cells assessed as increase in calcium mobilization by Calcium-6 dye based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Lophora

US Patent
LigandPNGBDBM50081701(3-[2-(dimethylamino)ethyl]-1H-indol-4-ol | 4-hydro...)
Affinity DataEC50: <1.00E+3nMAssay Description:i. Prepare the assay buffer following the table below;Reagent ConcentrationTris 50 mMCaCl2  4 mMBSA 0.1% (w/v)Adjust pH to 7.4 followed by 0.2 ...More data for this Ligand-Target Pair
In DepthDetails US Patent