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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
11
hits in this display
Target
Aurora kinase A
(Homo sapiens (Human))
Cyclacel
Curated by
ChEMBL
Ligand
BDBM8066
(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 37 | 4...)
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Affinity Data
Ki: 6.90nM
Assay Description:
Inhibition of human recombinant Aurora A after 30 mins
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
DrugBank
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
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Target
Aurora kinase B
(Homo sapiens (Human))
Cyclacel
Curated by
ChEMBL
Ligand
BDBM8066
(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 37 | 4...)
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Affinity Data
Ki: 15nM
Assay Description:
Inhibition of human recombinant Aurora B after 60 mins
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
DrugBank
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
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Target
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1
(Homo sapiens (Human))
Cyclacel
Ligand
BDBM8066
(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 37 | 4...)
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Affinity Data
Ki: 220nM ΔG°: -38.6kJ/mole
T: 2°C
Assay Description:
In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
Ligand Info
DrugBank
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Cyclin-dependent kinase 2
(Homo sapiens (Human))
Cyclacel
Curated by
ChEMBL
Ligand
BDBM8066
(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 37 | 4...)
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Copy InChI
Affinity Data
Ki: 251nM
Assay Description:
Inhibition of CDK2
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
DrugBank
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
MMDB
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Cyclin-dependent kinase 9
(Homo sapiens (Human))
Cyclacel
Curated by
ChEMBL
Ligand
BDBM8066
(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 37 | 4...)
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Affinity Data
Ki: 575nM
Assay Description:
Inhibition of CDK9
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
DrugBank
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
(Homo sapiens (Human))
Cyclacel
Ligand
BDBM8066
(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 37 | 4...)
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Affinity Data
Ki: 960nM ΔG°: -34.9kJ/mole
T: 2°C
Assay Description:
In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
Ligand Info
DrugBank
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cyclin-dependent kinase 4
(Homo sapiens (Human))
Cyclacel
Curated by
ChEMBL
Ligand
BDBM8066
(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 37 | 4...)
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Affinity Data
Ki: 1.50E+3nM
Assay Description:
Inhibition of CDK4
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
DrugBank
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cyclin-dependent kinase 1
(Homo sapiens (Human))
Cyclacel
Curated by
ChEMBL
Ligand
BDBM8066
(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 37 | 4...)
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Affinity Data
Ki: 2.52E+3nM
Assay Description:
Inhibition of CDK1
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
DrugBank
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cyclin-dependent kinase 7
(Homo sapiens (Human))
Cyclacel
Curated by
ChEMBL
Ligand
BDBM8066
(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 37 | 4...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 4.01E+3nM
Assay Description:
Inhibition of CDK7
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
DrugBank
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cyclin-dependent kinase 2
(Homo sapiens (Human))
Cyclacel
Curated by
ChEMBL
Ligand
BDBM8066
(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 37 | 4...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 220nM
Assay Description:
In vitro inhibition assay using human recombinant CDK2 and human recombinant cyclin A2.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
DrugBank
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
MMDB
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Cyclin-A2/Cyclin-dependent kinase 2
(Homo sapiens (Human))
Cyclacel
Ligand
BDBM8066
(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 37 | 4...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 220nM
Assay Description:
In vitro inhibition assay using human recombinant CDK2 and human recombinant cyclin A2.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
Ligand Info
DrugBank
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
DrugBank
MMDB
PDB
3D Structure (crystal)
Copy BDB DOI