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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
28
hits in this display
Target
Substance-K receptor
(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50071112
(CHEMBL56835 | N-[4-(4-Acetylamino-4-phenyl-piperid...)
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Affinity Data
Ki: 0.230nM
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Target
Substance-K receptor
(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50071112
(CHEMBL56835 | N-[4-(4-Acetylamino-4-phenyl-piperid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.400nM
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Target
Substance-K receptor
(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50071112
(CHEMBL56835 | N-[4-(4-Acetylamino-4-phenyl-piperid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.440nM
More data for this Ligand-Target Pair
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Target
Substance-K receptor
(Rattus norvegicus (Rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50071484
(CHEMBL308148 | N-[(R)-4-(4-Acetylamino-4-phenyl-pi...)
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Affinity Data
Ki: 0.5nM
Assay Description:
Inhibition of [125I]-NKA binding to neurokinin NK2 receptor from rat duodenum membranes
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Target
Substance-K receptor
(Bos taurus)
St. John'S University
Curated by
ChEMBL
Ligand
BDBM50071484
(CHEMBL308148 | N-[(R)-4-(4-Acetylamino-4-phenyl-pi...)
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Affinity Data
Ki: 0.5nM
Assay Description:
Binding affinity against bovine Tachykinin receptor 2
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Target
Substance-K receptor
(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50071484
(CHEMBL308148 | N-[(R)-4-(4-Acetylamino-4-phenyl-pi...)
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Affinity Data
Ki: 0.5nM
Assay Description:
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
More data for this Ligand-Target Pair
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Target
Substance-P receptor
(Rattus norvegicus (rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50071484
(CHEMBL308148 | N-[(R)-4-(4-Acetylamino-4-phenyl-pi...)
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Affinity Data
Ki: 0.510nM
Assay Description:
Tested in vitro to inhibit the binding of [125I]-NKA to its receptor in rat duodenum membrane
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Target
Substance-K receptor
(Bos taurus)
St. John'S University
Curated by
ChEMBL
Ligand
BDBM50071112
(CHEMBL56835 | N-[4-(4-Acetylamino-4-phenyl-piperid...)
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Affinity Data
Ki: 0.710nM
More data for this Ligand-Target Pair
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Target
Substance-K receptor
(HAMSTER)
TBA
Curated by
ChEMBL
Ligand
BDBM50071484
(CHEMBL308148 | N-[(R)-4-(4-Acetylamino-4-phenyl-pi...)
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Affinity Data
Ki: 1.20nM
Assay Description:
The compound was evaluated for the inhibition of [125I]-NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranes
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Target
Substance-K receptor
(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50071112
(CHEMBL56835 | N-[4-(4-Acetylamino-4-phenyl-piperid...)
Copy SMILES
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Affinity Data
Ki: 1.75nM
Assay Description:
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
More data for this Ligand-Target Pair
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Target
Substance-K receptor
(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50071112
(CHEMBL56835 | N-[4-(4-Acetylamino-4-phenyl-piperid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.80nM
Assay Description:
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
More data for this Ligand-Target Pair
Target Info
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Target
Substance-K receptor
(HAMSTER)
TBA
Curated by
ChEMBL
Ligand
BDBM50071112
(CHEMBL56835 | N-[4-(4-Acetylamino-4-phenyl-piperid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 7.32nM
More data for this Ligand-Target Pair
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Target
Neuromedin-K receptor
(GUINEA PIG)
Hoechst Marion Roussel
Curated by
PDSP K
i
Database
Ligand
BDBM50071112
(CHEMBL56835 | N-[4-(4-Acetylamino-4-phenyl-piperid...)
Copy SMILES
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Affinity Data
Ki: 208nM
More data for this Ligand-Target Pair
Target Info
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Target
Substance-P receptor
(GUINEA PIG)
Hoechst Marion Roussel
Curated by
PDSP K
i
Database
Ligand
BDBM50071112
(CHEMBL56835 | N-[4-(4-Acetylamino-4-phenyl-piperid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 217nM
More data for this Ligand-Target Pair
Target Info
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Target
Substance-P receptor
(Homo sapiens (Human))
Schering-Plough Research Institute
Curated by
PDSP K
i
Database
Ligand
BDBM50071112
(CHEMBL56835 | N-[4-(4-Acetylamino-4-phenyl-piperid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 273nM
More data for this Ligand-Target Pair
Target Info
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Target
Neuromedin-K receptor
(Homo sapiens (Human))
Sanofi Recherche
Curated by
PDSP K
i
Database
Ligand
BDBM50071112
(CHEMBL56835 | N-[4-(4-Acetylamino-4-phenyl-piperid...)
Copy SMILES
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Affinity Data
Ki: 368nM
More data for this Ligand-Target Pair
Target Info
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Target
Substance-P receptor
(Homo sapiens (Human))
Schering-Plough Research Institute
Curated by
PDSP K
i
Database
Ligand
BDBM50071112
(CHEMBL56835 | N-[4-(4-Acetylamino-4-phenyl-piperid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 454nM
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Substance-P receptor
(Homo sapiens (Human))
Schering-Plough Research Institute
Curated by
PDSP K
i
Database
Ligand
BDBM50071112
(CHEMBL56835 | N-[4-(4-Acetylamino-4-phenyl-piperid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 593nM
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Neuromedin-K receptor
(Homo sapiens (Human))
Sanofi Recherche
Curated by
PDSP K
i
Database
Ligand
BDBM50071112
(CHEMBL56835 | N-[4-(4-Acetylamino-4-phenyl-piperid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 707nM
More data for this Ligand-Target Pair
Target Info
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Target
Substance-K receptor
(Rattus norvegicus (Rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50071484
(CHEMBL308148 | N-[(R)-4-(4-Acetylamino-4-phenyl-pi...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 945nM
Assay Description:
The compound was evaluated for the inhibition of [125I]-NKA binding to Tachykinin receptor 2 from rat duodenum membranes
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Neuromedin-K receptor
(Homo sapiens (Human))
Sanofi Recherche
Curated by
PDSP K
i
Database
Ligand
BDBM50071112
(CHEMBL56835 | N-[4-(4-Acetylamino-4-phenyl-piperid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.28E+3nM
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Substance-K receptor
(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50071484
(CHEMBL308148 | N-[(R)-4-(4-Acetylamino-4-phenyl-pi...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.130nM
Assay Description:
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
More data for this Ligand-Target Pair
Target Info
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Target
Substance-K receptor
(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50071484
(CHEMBL308148 | N-[(R)-4-(4-Acetylamino-4-phenyl-pi...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.440nM
Assay Description:
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
More data for this Ligand-Target Pair
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Copy BDB DOI
Target
Substance-K receptor
(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50071484
(CHEMBL308148 | N-[(R)-4-(4-Acetylamino-4-phenyl-pi...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.800nM
Assay Description:
Binding affinity was determined against human NK2 receptor in CHO cells using [125I]-neurokinin A as radioligand
More data for this Ligand-Target Pair
Target Info
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KEGG
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antibodypedia
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CHEMBL
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Copy BDB DOI
Target
Substance-K receptor
(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals
Curated by
PDSP K
i
Database
Ligand
BDBM50071112
(CHEMBL56835 | N-[4-(4-Acetylamino-4-phenyl-piperid...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 8.90nM
Assay Description:
Binding affinity towards human Tachykinin receptor 2 using [125I]- NKA radioligand expressed in CHO cells
More data for this Ligand-Target Pair
Target Info
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Target
Neuromedin-K receptor
(GUINEA PIG)
Hoechst Marion Roussel
Curated by
PDSP K
i
Database
Ligand
BDBM50071484
(CHEMBL308148 | N-[(R)-4-(4-Acetylamino-4-phenyl-pi...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 208nM
Assay Description:
NK3 IC50 determined using [125I]-Bolton Hunter labeled eledoisin at NK3 receptors from guinea pig cerebral cortex
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Target
Substance-P receptor
(Homo sapiens (Human))
Schering-Plough Research Institute
Curated by
PDSP K
i
Database
Ligand
BDBM50071484
(CHEMBL308148 | N-[(R)-4-(4-Acetylamino-4-phenyl-pi...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 593nM
Assay Description:
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Substance-P receptor
(Homo sapiens (Human))
Schering-Plough Research Institute
Curated by
PDSP K
i
Database
Ligand
BDBM50071484
(CHEMBL308148 | N-[(R)-4-(4-Acetylamino-4-phenyl-pi...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 800nM
Assay Description:
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
More data for this Ligand-Target Pair
Target Info
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KEGG
UniProtKB/SwissProt
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Copy BDB DOI