Home
About
Info
Download
WebServices
Contact
Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
8
hits in this display
Target
Leukotriene A-4 hydrolase
(Homo sapiens (Human))
Goethe-University Frankfurt
Curated by
ChEMBL
Ligand
BDBM50116538
(3-{[3-(4-Benzyl-phenoxy)-propyl]-methyl-amino}-pro...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3nM
Assay Description:
Non-competitive inhibition of human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H using varying levels of L-arginine-7-amino...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Leukotriene A-4 hydrolase
(Homo sapiens (Human))
Goethe-University Frankfurt
Curated by
ChEMBL
Ligand
BDBM50116538
(3-{[3-(4-Benzyl-phenoxy)-propyl]-methyl-amino}-pro...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.5nM
Assay Description:
Inhibition of human leukotriene A4 hydrolase (LTA-4).
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Leukotriene A-4 hydrolase
(Homo sapiens (Human))
Goethe-University Frankfurt
Curated by
ChEMBL
Ligand
BDBM50116538
(3-{[3-(4-Benzyl-phenoxy)-propyl]-methyl-amino}-pro...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.5nM
Assay Description:
Inhibition of leukotriene A4 hydrolase in human recombinant assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Leukotriene A-4 hydrolase
(Homo sapiens (Human))
Goethe-University Frankfurt
Curated by
ChEMBL
Ligand
BDBM50116538
(3-{[3-(4-Benzyl-phenoxy)-propyl]-methyl-amino}-pro...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 6nM
Assay Description:
Inhibition of human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H using L-arginine-7-amino-4-Methylcoumarine as substrate pr...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Leukotriene A-4 hydrolase
(Homo sapiens (Human))
Goethe-University Frankfurt
Curated by
ChEMBL
Ligand
BDBM50116538
(3-{[3-(4-Benzyl-phenoxy)-propyl]-methyl-amino}-pro...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 49nM
Assay Description:
Inhibition of human whole blood LTB-4 production (Leukotriene B-4).
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Leukotriene A-4 hydrolase
(Homo sapiens (Human))
Goethe-University Frankfurt
Curated by
ChEMBL
Ligand
BDBM50116538
(3-{[3-(4-Benzyl-phenoxy)-propyl]-methyl-amino}-pro...)
Copy SMILES
Copy InChI
Affinity Data
Kd: 60nM
Assay Description:
Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 15 degC by ITC method
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Leukotriene A-4 hydrolase
(Homo sapiens (Human))
Goethe-University Frankfurt
Curated by
ChEMBL
Ligand
BDBM50116538
(3-{[3-(4-Benzyl-phenoxy)-propyl]-methyl-amino}-pro...)
Copy SMILES
Copy InChI
Affinity Data
Kd: 290nM
Assay Description:
Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 25 degC by ITC method
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Leukotriene A-4 hydrolase
(Homo sapiens (Human))
Goethe-University Frankfurt
Curated by
ChEMBL
Ligand
BDBM50116538
(3-{[3-(4-Benzyl-phenoxy)-propyl]-methyl-amino}-pro...)
Copy SMILES
Copy InChI
Affinity Data
Kd: 350nM
Assay Description:
Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 35 degC by ITC method
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI