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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 21 hits in this display   

TargetD(2) dopamine receptor(Homo sapiens (Human))
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50056443((R)-5-Methylamino-5,6-dihydro-1H,4H-imidazo[4,5,1-...)
Affinity DataKi:  9nMAssay Description:Binding affinity towards Dopamine receptor D2 by displacement of [3H]-U-86,170.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50056443((R)-5-Methylamino-5,6-dihydro-1H,4H-imidazo[4,5,1-...)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]7-OH-DPAT from human D2 receptor transfected in HEK293 cells measured after 60 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50056443((R)-5-Methylamino-5,6-dihydro-1H,4H-imidazo[4,5,1-...)
Affinity DataKi:  46nMAssay Description:Displacement of [3H]-(R)-(+)-7-OH-DPAT from human dopamine D2 receptor expressed in HEK293 cell membranes after 90 mins by micro beta scintillation c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50056443((R)-5-Methylamino-5,6-dihydro-1H,4H-imidazo[4,5,1-...)
Affinity DataKi:  73nMAssay Description:Binding affinity towards Serotonin 5-hydroxytryptamine 1A receptor by displacement of [3H]-(+)-8-OH-DPAT.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Columbia University College Of Physicians And Surgeons

Curated by ChEMBL
LigandPNGBDBM50056443((R)-5-Methylamino-5,6-dihydro-1H,4H-imidazo[4,5,1-...)
Affinity DataKi:  546nMAssay Description:Displacement of [3H]7-OH-DPAT from human D3 receptor transfected in HEK293 cells measured after 60 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Columbia University College Of Physicians And Surgeons

Curated by ChEMBL
LigandPNGBDBM50056443((R)-5-Methylamino-5,6-dihydro-1H,4H-imidazo[4,5,1-...)
Affinity DataKi:  573nMAssay Description:Displacement of [3H]-(R)-(+)-7-OH-DPAT from human dopamine D3 receptor expressed in HEK293 cell membranes after 90 mins by micro beta scintillation c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Columbia University College Of Physicians And Surgeons

Curated by ChEMBL
LigandPNGBDBM50056443((R)-5-Methylamino-5,6-dihydro-1H,4H-imidazo[4,5,1-...)
Affinity DataKi:  2.33E+3nMAssay Description:Binding affinity towards Dopamine receptor D3 by displacement of [3H]-(+)-7-OH-DPAT.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Columbia University College Of Physicians And Surgeons

Curated by ChEMBL
LigandPNGBDBM50056443((R)-5-Methylamino-5,6-dihydro-1H,4H-imidazo[4,5,1-...)
Affinity DataKi:  6.33E+3nMAssay Description:Displacement of [3H]N-methylspiperone from human D3 receptor transfected in HEK293 cells measured after 60 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50056443((R)-5-Methylamino-5,6-dihydro-1H,4H-imidazo[4,5,1-...)
Affinity DataKi:  1.63E+4nMAssay Description:Displacement of [3H]N-methylspiperone from human D2 receptor transfected in HEK293 cells measured after 60 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50056443((R)-5-Methylamino-5,6-dihydro-1H,4H-imidazo[4,5,1-...)
Affinity DataEC50:  75nMAssay Description:Compound was evaluated for its binding affinity against Toxoplasma gondii purine nucleoside phosphorylase from cystic strain ME 49 (value indicates c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50056443((R)-5-Methylamino-5,6-dihydro-1H,4H-imidazo[4,5,1-...)
Affinity DataEC50:  501nMAssay Description:Agonist activity at renilla luciferase-tagged human dopamine D2 receptor expressed in HEK293 cells coexpressing mVenus-fused beta-arrestin 2 assessed...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50056443((R)-5-Methylamino-5,6-dihydro-1H,4H-imidazo[4,5,1-...)
Affinity DataEC50:  543nMAssay Description:In vitro binding affinity at human cloned dopamine receptor D2 (short) stably expressed in CHO cells by [3H]spiperone displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50056443((R)-5-Methylamino-5,6-dihydro-1H,4H-imidazo[4,5,1-...)
Affinity DataEC50:  10.8nMAssay Description:In vitro effective concentration tested on HEK293 cells co-transfected with rat Dopamine receptor D2 using FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50056443((R)-5-Methylamino-5,6-dihydro-1H,4H-imidazo[4,5,1-...)
Affinity DataEC50:  35nMAssay Description:In vitro effective concentration tested on HEK293 cells co-transfected with ferret Dopamine receptor D2 using FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50056443((R)-5-Methylamino-5,6-dihydro-1H,4H-imidazo[4,5,1-...)
Affinity DataEC50:  165nMAssay Description:In vitro effective concentration tested on HEK293 cells co-transfected with human Dopamine receptor D2 using FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50056443((R)-5-Methylamino-5,6-dihydro-1H,4H-imidazo[4,5,1-...)
Affinity DataEC50:  4.60nMAssay Description:Agonist activity at recombinant human D2 receptor expressing in CHO cells assessed as receptor mediated stimulation of mitogenesis measured as [3H]th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50056443((R)-5-Methylamino-5,6-dihydro-1H,4H-imidazo[4,5,1-...)
Affinity DataEC50:  32nMAssay Description:Agonist activity at human dopamine D2 receptor expressed in HEK293 cells assessed as cAMP inhibition by BRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50056443((R)-5-Methylamino-5,6-dihydro-1H,4H-imidazo[4,5,1-...)
Affinity DataEC50:  65nMAssay Description:Agonist activity at recombinant human D2 receptor expressing in CHOp cells assessed as receptor mediated stimulation of mitogenesis measured as [3H]t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Columbia University College Of Physicians And Surgeons

Curated by ChEMBL
LigandPNGBDBM50056443((R)-5-Methylamino-5,6-dihydro-1H,4H-imidazo[4,5,1-...)
Affinity DataEC50:  186nMAssay Description:Agonist activity at human D3 receptor transfected in HEK293T cells by BRET based G0 activation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50056443((R)-5-Methylamino-5,6-dihydro-1H,4H-imidazo[4,5,1-...)
Affinity DataEC50:  60nMAssay Description:Agonist activity at human D2 receptor transfected in HEK293T cells by BRET based G0 activation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Columbia University College Of Physicians And Surgeons

Curated by ChEMBL
LigandPNGBDBM50056443((R)-5-Methylamino-5,6-dihydro-1H,4H-imidazo[4,5,1-...)
Affinity DataEC50:  669nMAssay Description:Agonist activity at recombinant human D3 receptor expressing in CHOp cells assessed as receptor mediated stimulation of mitogenesis measured as [3H]t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed