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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
5
hits in this display
Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
University Of Kentucky
Curated by
ChEMBL
Ligand
BDBM50192907
(10R-hydroxylobel-7-ene | CHEMBL217815)
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Affinity Data
Ki: 290nM
Assay Description:
Inhibition of [3H]DA uptake at DAT in rat striatal synaptosomes
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Synaptic vesicular amine transporter
(Rattus norvegicus (Rat))
University Of Kentucky
Curated by
ChEMBL
Ligand
BDBM50192907
(10R-hydroxylobel-7-ene | CHEMBL217815)
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Affinity Data
Ki: 590nM
Assay Description:
Inhibition of [3H]DTBZ binding to VMAT2 in rat synaptic vesicle membrane
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
University Of Kentucky
Curated by
ChEMBL
Ligand
BDBM50192907
(10R-hydroxylobel-7-ene | CHEMBL217815)
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Affinity Data
Ki: 7.50E+3nM
Assay Description:
Inhibition of [3H]5-HT uptake at SERT in rat hippocampal synaptosomes
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat))
University Of Kentucky
Curated by
ChEMBL
Ligand
BDBM50192907
(10R-hydroxylobel-7-ene | CHEMBL217815)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of [3H]NIC binding to alpha4beta2 nAChR in rat brain membrane
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat))
University Of Kentucky
Curated by
ChEMBL
Ligand
BDBM50192907
(10R-hydroxylobel-7-ene | CHEMBL217815)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of [3H]MLA binding to alpha7 nAChR in rat brain membrane
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI