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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
49
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Target
Neuronal acetylcholine receptor subunit alpha-2
(Rattus norvegicus (Rat))
The Danish University Of Pharmaceutical Sciences
Curated by
PDSP K
i
Database
Ligand
BDBM50047021
(2-(6-(2-hydroxy-2-phenylethyl)-1-methylpiperidin-2...)
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Affinity Data
Ki: 1.60nM
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Target
Neuronal acetylcholine receptor subunit alpha-4
(Homo sapiens (Human))
Barrow Neurological Institute
Curated by
PDSP K
i
Database
Ligand
BDBM50047021
(2-(6-(2-hydroxy-2-phenylethyl)-1-methylpiperidin-2...)
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Affinity Data
Ki: 1.90nM
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Target
Neuronal acetylcholine receptor subunit alpha-4
(Homo sapiens (Human))
Barrow Neurological Institute
Curated by
PDSP K
i
Database
Ligand
BDBM50047021
(2-(6-(2-hydroxy-2-phenylethyl)-1-methylpiperidin-2...)
Copy SMILES
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Affinity Data
Ki: 1.92nM
More data for this Ligand-Target Pair
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Target
Neuronal acetylcholine receptor subunit alpha-4
(Rattus norvegicus (Rat))
The Danish University Of Pharmaceutical Sciences
Curated by
PDSP K
i
Database
Ligand
BDBM50047021
(2-(6-(2-hydroxy-2-phenylethyl)-1-methylpiperidin-2...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.20nM
More data for this Ligand-Target Pair
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Target
Soluble acetylcholine receptor
(Aplysia Californica)
Vu University Amsterdam
Curated by
ChEMBL
Ligand
BDBM50080818
((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
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Affinity Data
Ki: 2.51nM
Assay Description:
Displacement of [3H]epibatidine from Aplysia californica acetylcholine binding protein expressed using baculoviral system after 1.5 hrs by scintillat...
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Target
Synaptic vesicular amine transporter
(Rattus norvegicus (Rat))
University Of Kentucky
Curated by
ChEMBL
Ligand
BDBM50080818
((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
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Affinity Data
Ki: 4nM
Assay Description:
Inhibition constant against [3H]-nicotine binding to vesicular monoamine transporter-2 of rat brain membranes
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Target
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human))
University Of Hawaii At Hilo
Curated by
ChEMBL
Ligand
BDBM50422013
(LOBELINE | Lobeline Hydrochloride)
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Affinity Data
Ki: 4nM
Assay Description:
Binding affinity to alpha3beta4 nicotine acetylcholine receptor (unknown origin) after 90 mins by radioligand displacement assay
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Target
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human))
University Of Hawaii At Hilo
Curated by
ChEMBL
Ligand
BDBM50422013
(LOBELINE | Lobeline Hydrochloride)
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Affinity Data
Ki: 5nM
Assay Description:
Binding affinity to alpha4beta2 (unknown origin)
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Target
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human))
University Of Hawaii At Hilo
Curated by
ChEMBL
Ligand
BDBM50422013
(LOBELINE | Lobeline Hydrochloride)
Copy SMILES
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Affinity Data
Ki: 5nM
Assay Description:
Binding affinity to alpha4beta2 (unknown origin)
More data for this Ligand-Target Pair
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Target
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human))
University Of Hawaii At Hilo
Curated by
ChEMBL
Ligand
BDBM50080818
((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
Copy SMILES
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Affinity Data
Ki: 5.01nM
Assay Description:
Displacement of [3H]epibatidine from human nAChR alpha4beta2 receptor expressed in human HEK293T cells by scintillation counting
More data for this Ligand-Target Pair
Target Info
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Target
Neuronal acetylcholine receptor subunit alpha-5
(RAT)
Targacept
Curated by
PDSP K
i
Database
Ligand
BDBM50047021
(2-(6-(2-hydroxy-2-phenylethyl)-1-methylpiperidin-2...)
Copy SMILES
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Affinity Data
Ki: 6.39nM
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Target
Nicotinic acetylcholine receptor
(RAT)
R. J. Reynolds Tobacco
Curated by
PDSP K
i
Database
Ligand
BDBM50047021
(2-(6-(2-hydroxy-2-phenylethyl)-1-methylpiperidin-2...)
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Affinity Data
Ki: 9nM
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Target
Neuronal acetylcholine receptor subunit alpha-4
(Rattus norvegicus (Rat))
The Danish University Of Pharmaceutical Sciences
Curated by
PDSP K
i
Database
Ligand
BDBM50047021
(2-(6-(2-hydroxy-2-phenylethyl)-1-methylpiperidin-2...)
Copy SMILES
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Affinity Data
Ki: 12.1nM
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Target
Nicotinic acetylcholine receptor
(RAT)
R. J. Reynolds Tobacco
Curated by
PDSP K
i
Database
Ligand
BDBM50047021
(2-(6-(2-hydroxy-2-phenylethyl)-1-methylpiperidin-2...)
Copy SMILES
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Affinity Data
Ki: 15.5nM
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Target
Cytochrome P450 2D6
(Homo sapiens (Human))
Institut F£R Toxikologie
Curated by
ChEMBL
Ligand
BDBM50422013
(LOBELINE | Lobeline Hydrochloride)
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Affinity Data
Ki: 120nM
Assay Description:
Inhibitory constant for cytochrome P450 2D6
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Target
Neuronal acetylcholine receptor subunit alpha-4
(Rattus norvegicus (Rat))
The Danish University Of Pharmaceutical Sciences
Curated by
PDSP K
i
Database
Ligand
BDBM50047021
(2-(6-(2-hydroxy-2-phenylethyl)-1-methylpiperidin-2...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 120nM
More data for this Ligand-Target Pair
Target Info
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Target
Neuronal acetylcholine receptor subunit alpha-2
(Rattus norvegicus (Rat))
The Danish University Of Pharmaceutical Sciences
Curated by
PDSP K
i
Database
Ligand
BDBM50047021
(2-(6-(2-hydroxy-2-phenylethyl)-1-methylpiperidin-2...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 280nM
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Target
Synaptic vesicular amine transporter
(Rattus norvegicus (Rat))
University Of Kentucky
Curated by
ChEMBL
Ligand
BDBM50080818
((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
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Affinity Data
Ki: 470nM
Assay Description:
Inhibition of [3H]DA uptake at VMAT2 in rat striatal synaptic vesicles
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Target
Synaptic vesicular amine transporter
(Rattus norvegicus (Rat))
University Of Kentucky
Curated by
ChEMBL
Ligand
BDBM50422013
(LOBELINE | Lobeline Hydrochloride)
Copy SMILES
Copy InChI
Affinity Data
Ki: 470nM
Assay Description:
Inhibition of [3H]dopamine uptake at VMAT2 in rat brain synaptic vesicle by liquid scintillation spectroscopy
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Target
Neuronal acetylcholine receptor subunit alpha-3
(Rattus norvegicus (Rat))
The Danish University Of Pharmaceutical Sciences
Curated by
PDSP K
i
Database
Ligand
BDBM50047021
(2-(6-(2-hydroxy-2-phenylethyl)-1-methylpiperidin-2...)
Copy SMILES
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Affinity Data
Ki: 480nM
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Target
Acetylcholine-binding protein
(Lymnaea stagnalis)
Vu University Amsterdam
Curated by
ChEMBL
Ligand
BDBM50080818
((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
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Affinity Data
Ki: 631nM
Assay Description:
Displacement of [3H]epibatidine from Lymnaea stagnalis acetylcholine binding protein expressed using baculoviral system after 1.5 hrs by scintillatio...
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Target
Synaptic vesicular amine transporter
(Homo sapiens (Human))
Organix
Curated by
ChEMBL
Ligand
BDBM50080818
((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
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Affinity Data
Ki: 1.84E+3nM
Assay Description:
Displacement of [3H]reserpine from human VMAT2 expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method
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Target
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human))
University Of Kentucky
Curated by
PDSP K
i
Database
Ligand
BDBM50047021
(2-(6-(2-hydroxy-2-phenylethyl)-1-methylpiperidin-2...)
Copy SMILES
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Affinity Data
Ki: 1.87E+3nM
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Target
Synaptic vesicular amine transporter
(Homo sapiens (Human))
Organix
Curated by
ChEMBL
Ligand
BDBM50080818
((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
Copy SMILES
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Affinity Data
Ki: 1.95E+3nM
Assay Description:
Displacement of [3H](+)-syn-Ethyl 1-(2-(2,4-Dioxo-1,2-dihydroquinazolin-3(4H)-yl)ethyl)-4-(4-fluorophenyl)piperidine-3-carboxylate from human VMAT2 e...
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Target
Synaptic vesicular amine transporter
(Rattus norvegicus (Rat))
University Of Kentucky
Curated by
ChEMBL
Ligand
BDBM50422013
(LOBELINE | Lobeline Hydrochloride)
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Affinity Data
Ki: 2.76E+3nM
Assay Description:
Displacement of [3H]DTBZ from VMAT2 dihydrotetrabenazine binding site in rat brain synaptic vesicle by scintillation counting
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Target
Synaptic vesicular amine transporter
(Rattus norvegicus (Rat))
University Of Kentucky
Curated by
ChEMBL
Ligand
BDBM50080818
((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.76E+3nM
Assay Description:
Inhibition constant against [3H]-dihydrotetrabenazine binding to vesicular monoamine transporter-2 of rat synaptic vesicle membranes
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Target
Synaptic vesicular amine transporter
(Rattus norvegicus (Rat))
University Of Kentucky
Curated by
ChEMBL
Ligand
BDBM50080818
((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.76E+3nM
Assay Description:
Inhibition of [3H]DTBZ binding to VMAT2 in rat synaptic vesicle membranes
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Target
Synaptic vesicular amine transporter
(Rattus norvegicus (Rat))
University Of Kentucky
Curated by
ChEMBL
Ligand
BDBM50422013
(LOBELINE | Lobeline Hydrochloride)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.76E+3nM
Assay Description:
Inhibition of [3H]DTBZ binding to VMAT2 in rat synaptic vesicle membrane
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Target
Synaptic vesicular amine transporter
(Homo sapiens (Human))
Organix
Curated by
ChEMBL
Ligand
BDBM50422013
(LOBELINE | Lobeline Hydrochloride)
Copy SMILES
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Affinity Data
Ki: 2.76E+3nM
Assay Description:
Binding affinity to VMAT2 receptor
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Target
Synaptic vesicular amine transporter
(Rattus norvegicus (Rat))
University Of Kentucky
Curated by
ChEMBL
Ligand
BDBM50080818
((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
Copy SMILES
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Affinity Data
Ki: 2.76E+3nM
Assay Description:
Inhibition of 5 nM [3H]DTBZ binding to Vesicular Monoamine Transporter (VAMT2) of rat vesicle membranes
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Target
Synaptic vesicular amine transporter
(Rattus norvegicus (Rat))
University Of Kentucky
Curated by
ChEMBL
Ligand
BDBM50080818
((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.76E+3nM
Assay Description:
Displacement of [3H]dihydrotetrabenazine from vesicular monoamine transporter-2 in rat brain synaptosome
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Target
Sodium-dependent dopamine transporter
(Homo sapiens (Human))
University Of Kentucky
Curated by
PDSP K
i
Database
Ligand
BDBM50047021
(2-(6-(2-hydroxy-2-phenylethyl)-1-methylpiperidin-2...)
Copy SMILES
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Affinity Data
Ki: 5.40E+3nM
More data for this Ligand-Target Pair
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NCI pathway
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Target
Synaptic vesicular amine transporter
(Rattus norvegicus (Rat))
University Of Kentucky
Curated by
ChEMBL
Ligand
BDBM50422013
(LOBELINE | Lobeline Hydrochloride)
Copy SMILES
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Affinity Data
Ki: 5.46E+3nM
Assay Description:
Displacement of [3H]MTBZ from VMAT2 in rat whole brain vesicles by liquid scintillation spectrophotometry
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat))
University Of Kentucky
Curated by
ChEMBL
Ligand
BDBM50080818
((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
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Affinity Data
Ki: 6.26E+3nM
Assay Description:
Inhibition of 3 nM [3H]-MLA binding to Nicotinic acetylcholine receptor alpha7 of rat brain membranes
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Target
Synaptic vesicular amine transporter
(Rattus norvegicus (Rat))
University Of Kentucky
Curated by
ChEMBL
Ligand
BDBM50080818
((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
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Affinity Data
Ki: 6.26E+3nM
Assay Description:
Inhibition constant against [3H]-methyllycaconitine binding to vesicular monoamine transporter-2 of rat brain membranes
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat))
University Of Kentucky
Curated by
ChEMBL
Ligand
BDBM50422013
(LOBELINE | Lobeline Hydrochloride)
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Affinity Data
Ki: 6.60E+3nM
Assay Description:
Binding affinity to alpha3beta4 nicotine acetylcholine receptor (unknown origin) after 90 mins by radioligand displacement assay
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Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
Organix
Curated by
ChEMBL
Ligand
BDBM50080818
((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
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Affinity Data
Ki: 7.40E+3nM
Assay Description:
Displacement of [125I]DOI from human 5HT2A receptor expressed in HEK293 cell membranes
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Homo sapiens (Human))
Vu University Amsterdam
Curated by
ChEMBL
Ligand
BDBM50080818
((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
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Affinity Data
Ki: 7.94E+3nM
Assay Description:
Displacement of [3H]MLA from nAChR alpha7 receptor in human SH-SY5Y cells by scintillation counting
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat))
University Of Kentucky
Curated by
ChEMBL
Ligand
BDBM50047021
(2-(6-(2-hydroxy-2-phenylethyl)-1-methylpiperidin-2...)
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Ki: 8.88E+3nM
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat))
University Of Kentucky
Curated by
ChEMBL
Ligand
BDBM50047021
(2-(6-(2-hydroxy-2-phenylethyl)-1-methylpiperidin-2...)
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Affinity Data
Ki: >1.00E+4nM
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Target
Sodium-dependent serotonin transporter
(Homo sapiens (Human))
University Of Kentucky
Curated by
PDSP K
i
Database
Ligand
BDBM50047021
(2-(6-(2-hydroxy-2-phenylethyl)-1-methylpiperidin-2...)
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Affinity Data
Ki: >1.00E+4nM
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat))
University Of Kentucky
Curated by
ChEMBL
Ligand
BDBM50047021
(2-(6-(2-hydroxy-2-phenylethyl)-1-methylpiperidin-2...)
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Affinity Data
Ki: >1.00E+4nM
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Target
Synaptic vesicular amine transporter
(Homo sapiens (Human))
Organix
Curated by
ChEMBL
Ligand
BDBM50080818
((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Displacement of [3H]DHTB from human VMAT2 expressed in HEK293 cell membranes incubated for 90 mins by microbeta scintillation counting method
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Target
Synaptic vesicular amine transporter
(Mus musculus)
Organix
Curated by
ChEMBL
Ligand
BDBM50080818
((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
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Affinity Data
IC50: 381nM
Assay Description:
Inhibition of VMAT2 in C57Bl/6J mouse striatal membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addition ...
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Target
Synaptic vesicular amine transporter
(Homo sapiens (Human))
Organix
Curated by
ChEMBL
Ligand
BDBM50080818
((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
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Affinity Data
IC50: 4.20E+3nM
Assay Description:
Inhibition of human VMAT2 expressed in HEK293 cell membranes assessed as reduction in [3H[-5HT uptake pre-incubated for 10 mins before [3H[-5HT addit...
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Target
Histamine H1 receptor
(RAT)
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50422013
(LOBELINE | Lobeline Hydrochloride)
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Affinity Data
IC50: 1.12E+4nM
Assay Description:
Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting
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Target
Histamine H1 receptor
(Homo sapiens (Human))
University Of Oxford
Curated by
ChEMBL
Ligand
BDBM50422013
(LOBELINE | Lobeline Hydrochloride)
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Affinity Data
IC50: 4.47E+4nM
Assay Description:
Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence ...
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Target
Acetylcholine-binding protein
(Lymnaea stagnalis)
Vu University Amsterdam
Curated by
ChEMBL
Ligand
BDBM50422013
(LOBELINE | Lobeline Hydrochloride)
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Affinity Data
Kd: 630nM
Assay Description:
Binding affinity to Lymnaea stagnalis AChBP after 300 seconds by SPR biosensor analysis
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Target
Acetylcholine-binding protein
(Lymnaea stagnalis)
Vu University Amsterdam
Curated by
ChEMBL
Ligand
BDBM50422013
(LOBELINE | Lobeline Hydrochloride)
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Affinity Data
Kd: 631nM
Assay Description:
Binding affinity to Lymnaea stagnalis AChBP after 300 seconds by SPR biosensor analysis
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