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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 10 hits in this display   

TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303731((5R)-2-amino-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-3...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human BACE1 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303731((5R)-2-amino-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-3...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303731((5R)-2-amino-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-3...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human BACE1 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303731((5R)-2-amino-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-3...)
Affinity DataIC50:  2.33E+3nMAssay Description:Inhibition of human cathepsin D by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303731((5R)-2-amino-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-3...)
Affinity DataIC50:  4.18E+3nMAssay Description:Inhibition of human cathepsin D by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303731((5R)-2-amino-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-3...)
Affinity DataIC50:  7.54E+3nMAssay Description:Inhibition of human BACE2 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303731((5R)-2-amino-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-3...)
Affinity DataIC50:  9.69E+3nMAssay Description:Inhibition of human BACE2 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303731((5R)-2-amino-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-3...)
Affinity DataEC50:  270nMAssay Description:Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISAMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303731((5R)-2-amino-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-3...)
Affinity DataEC50:  20nMAssay Description:Inhibition of BACE1 by cell-based assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303731((5R)-2-amino-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-3...)
Affinity DataEC50:  70nMAssay Description:Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISAMore data for this Ligand-Target Pair