Compile Data Set for Download or QSAR
maximum 50k data

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 6 hits in this display   

TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329550((R)-2-amino-4-(3-(cyclopropylethynyl)phenyl)-4-(4-...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329550((R)-2-amino-4-(3-(cyclopropylethynyl)phenyl)-4-(4-...)
Affinity DataIC50:  70nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329550((R)-2-amino-4-(3-(cyclopropylethynyl)phenyl)-4-(4-...)
Affinity DataIC50:  100nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329550((R)-2-amino-4-(3-(cyclopropylethynyl)phenyl)-4-(4-...)
Affinity DataIC50:  3.75E+3nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329550((R)-2-amino-4-(3-(cyclopropylethynyl)phenyl)-4-(4-...)
Affinity DataIC50:  7.70E+3nMAssay Description:Inhibition of renin by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329550((R)-2-amino-4-(3-(cyclopropylethynyl)phenyl)-4-(4-...)
Affinity DataEC50:  100nMAssay Description:Inhibition of human recombinant BACE1 expressed in CHO cells assessed as reduction in amyloid beta level by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed