Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 5 hits in this display   

TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329548((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(6-...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329548((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(6-...)
Affinity DataIC50:  320nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329548((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(6-...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329548((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(6-...)
Affinity DataIC50:  6.10E+3nMAssay Description:Inhibition of renin by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50329548((R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(6-...)
Affinity DataEC50:  70nMAssay Description:Inhibition of human recombinant BACE1 expressed in CHO cells assessed as reduction in amyloid beta level by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed