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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
59
hits in this display
Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(RAT)
TBA
Ligand
BDBM50452855
(Isoptpo Hyoscine | Scopolamine)
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Affinity Data
Ki: 0.0800nM
Assay Description:
Inhibition of [3H]pirenzepine binding to muscarinic receptor in rat cortical homogenates
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Target
Muscarinic acetylcholine receptor M4
(RAT)
Case Western Reserve University
Curated by
PDSP K
i
Database
Ligand
BDBM50015720
((hyoscine)3-Hydroxy-2-phenyl-propionic acid 9-meth...)
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Affinity Data
Ki: 0.140nM
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Target
Muscarinic acetylcholine receptor M3
(RAT)
Glaxo Group Research
Curated by
PDSP K
i
Database
Ligand
BDBM50015720
((hyoscine)3-Hydroxy-2-phenyl-propionic acid 9-meth...)
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Affinity Data
Ki: 0.180nM
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Target
Muscarinic acetylcholine receptor M1
(RAT)
Glaxo Group Research
Curated by
PDSP K
i
Database
Ligand
BDBM50015720
((hyoscine)3-Hydroxy-2-phenyl-propionic acid 9-meth...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.190nM
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Target
Muscarinic acetylcholine receptor
(PORCINE)
Case Western Reserve University
Curated by
PDSP K
i
Database
Ligand
BDBM50015720
((hyoscine)3-Hydroxy-2-phenyl-propionic acid 9-meth...)
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Affinity Data
Ki: 0.210nM
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Target
Muscarinic acetylcholine receptor
(RABBIT)
Glaxo Group Research
Curated by
PDSP K
i
Database
Ligand
BDBM50015720
((hyoscine)3-Hydroxy-2-phenyl-propionic acid 9-meth...)
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Affinity Data
Ki: 0.220nM
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Target
Muscarinic acetylcholine receptor M4
(bovine)
Case Western Reserve University
Curated by
PDSP K
i
Database
Ligand
BDBM50015720
((hyoscine)3-Hydroxy-2-phenyl-propionic acid 9-meth...)
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Affinity Data
Ki: 0.380nM
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Target
Muscarinic receptor M1
(Bos taurus)
Groningen University Hospital
Curated by
ChEMBL
Ligand
BDBM50452855
(Isoptpo Hyoscine | Scopolamine)
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Affinity Data
Ki: 0.410nM
Assay Description:
Binding affinity towards Muscarinic acetylcholine receptor M1 was determined in calf brain membrane
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Target
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM50015720
((hyoscine)3-Hydroxy-2-phenyl-propionic acid 9-meth...)
Copy SMILES
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Affinity Data
Ki: 0.440nM
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Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM50015720
((hyoscine)3-Hydroxy-2-phenyl-propionic acid 9-meth...)
Copy SMILES
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Affinity Data
Ki: 0.440nM
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Target
Muscarinic acetylcholine receptor M1
(RAT)
Glaxo Group Research
Curated by
PDSP K
i
Database
Ligand
BDBM50452855
(Isoptpo Hyoscine | Scopolamine)
Copy SMILES
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Affinity Data
Ki: 0.530nM
Assay Description:
Binding affinity towards rat Muscarinic acetylcholine receptor M1 was determined
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Target
Muscarinic acetylcholine receptor DM1
(Drosophila melanogaster)
University Of California
Curated by
ChEMBL
Ligand
BDBM50240039
(CHEBI:16794 | CHEMBL569713)
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Affinity Data
Ki: 0.700nM
Assay Description:
Displacement of [3H]AF-DX 384 from Drosophila melanogaster mAChR by scintillation counting
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Target
Muscarinic acetylcholine receptor M2
(RAT)
TBA
Curated by
PDSP K
i
Database
Ligand
BDBM50015720
((hyoscine)3-Hydroxy-2-phenyl-propionic acid 9-meth...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.800nM
More data for this Ligand-Target Pair
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Target
Muscarinic acetylcholine receptor M4
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM50015720
((hyoscine)3-Hydroxy-2-phenyl-propionic acid 9-meth...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.800nM
More data for this Ligand-Target Pair
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Target
Muscarinic acetylcholine receptor M4
(Chick)
Glaxo Group Research
Curated by
PDSP K
i
Database
Ligand
BDBM50015720
((hyoscine)3-Hydroxy-2-phenyl-propionic acid 9-meth...)
Copy SMILES
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Affinity Data
Ki: 0.930nM
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Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM50015720
((hyoscine)3-Hydroxy-2-phenyl-propionic acid 9-meth...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.10nM
More data for this Ligand-Target Pair
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Target
Muscarinic acetylcholine receptor DM1
(Drosophila melanogaster)
University Of California
Curated by
ChEMBL
Ligand
BDBM50240039
(CHEBI:16794 | CHEMBL569713)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.10nM
Assay Description:
Displacement of [3H]QNB from Drosophila melanogaster mAChR by scintillation counting
More data for this Ligand-Target Pair
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Target
Muscarinic acetylcholine receptor M5
(Homo sapiens (Human))
University Of W£Rzburg
Curated by
ChEMBL
Ligand
BDBM50452855
(Isoptpo Hyoscine | Scopolamine)
Copy SMILES
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Affinity Data
Ki: 1.30nM
Assay Description:
Displacement of [3H]-NMS from wild-type human muscarinic M5 receptor expressed in CHO-K1 cells by liquid scintillation counting
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Target
Muscarinic acetylcholine receptor M2
(RAT)
TBA
Curated by
PDSP K
i
Database
Ligand
BDBM50015720
((hyoscine)3-Hydroxy-2-phenyl-propionic acid 9-meth...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.41nM
More data for this Ligand-Target Pair
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Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM50015720
((hyoscine)3-Hydroxy-2-phenyl-propionic acid 9-meth...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2nM
More data for this Ligand-Target Pair
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Target
Muscarinic acetylcholine receptor M5
(Homo sapiens (Human))
University Of W£Rzburg
Curated by
ChEMBL
Ligand
BDBM50015720
((hyoscine)3-Hydroxy-2-phenyl-propionic acid 9-meth...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.07nM
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Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM50452855
(Isoptpo Hyoscine | Scopolamine)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3nM
Assay Description:
Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting
More data for this Ligand-Target Pair
Target Info
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Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM50452855
(Isoptpo Hyoscine | Scopolamine)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.30nM
Assay Description:
Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting
More data for this Ligand-Target Pair
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Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM50452855
(Isoptpo Hyoscine | Scopolamine)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.30nM
Assay Description:
Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting
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Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM50452855
(Isoptpo Hyoscine | Scopolamine)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.5nM
Assay Description:
Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting
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Target
Muscarinic acetylcholine receptor M2
(RAT)
TBA
Curated by
PDSP K
i
Database
Ligand
BDBM50452855
(Isoptpo Hyoscine | Scopolamine)
Copy SMILES
Copy InChI
Affinity Data
Ki: 4.60nM
Assay Description:
Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determined
More data for this Ligand-Target Pair
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Target
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM50368127
(Isoptpo Hyoscine | SCOPOLAMINE)
Copy SMILES
Copy InChI
Affinity Data
Ki: 6.5nM
Assay Description:
Displacement of [3H]NMS from human M3 muscarinic receptor expressed in CHO-K1 cells
More data for this Ligand-Target Pair
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Target
Muscarinic acetylcholine receptor M2
(RAT)
TBA
Curated by
PDSP K
i
Database
Ligand
BDBM50015720
((hyoscine)3-Hydroxy-2-phenyl-propionic acid 9-meth...)
Copy SMILES
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Affinity Data
Ki: 7nM
More data for this Ligand-Target Pair
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Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM50368127
(Isoptpo Hyoscine | SCOPOLAMINE)
Copy SMILES
Copy InChI
Affinity Data
Ki: 7.5nM
Assay Description:
Displacement of [3H]NMS from human M1 muscarinic receptor expressed in CHO-K1 cells
More data for this Ligand-Target Pair
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Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM50368127
(Isoptpo Hyoscine | SCOPOLAMINE)
Copy SMILES
Copy InChI
Affinity Data
Ki: 9.5nM
Assay Description:
Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells
More data for this Ligand-Target Pair
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Target
Muscarinic acetylcholine receptor M5
(Homo sapiens (Human))
University Of W£Rzburg
Curated by
ChEMBL
Ligand
BDBM50368127
(Isoptpo Hyoscine | SCOPOLAMINE)
Copy SMILES
Copy InChI
Affinity Data
Ki: 18nM
Assay Description:
Displacement of [3H]NMS from human M5 muscarinic receptor expressed in CHO-K1 cells
More data for this Ligand-Target Pair
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Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM50452855
(Isoptpo Hyoscine | Scopolamine)
Copy SMILES
Copy InChI
Affinity Data
Ki: 29nM
Assay Description:
Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting
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Target
Muscarinic acetylcholine receptor M4
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM50368127
(Isoptpo Hyoscine | SCOPOLAMINE)
Copy SMILES
Copy InChI
Affinity Data
Ki: 37nM
Assay Description:
Displacement of [3H]NMS from human M4 muscarinic receptor expressed in CHO-K1 cells
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
Schering-Plough
Curated by
PDSP K
i
Database
Ligand
BDBM50015720
((hyoscine)3-Hydroxy-2-phenyl-propionic acid 9-meth...)
Copy SMILES
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Affinity Data
Ki: >1.00E+4nM
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Target
Histamine H1 receptor
(RAT)
TBA
Curated by
PDSP K
i
Database
Ligand
BDBM50015720
((hyoscine)3-Hydroxy-2-phenyl-propionic acid 9-meth...)
Copy SMILES
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Affinity Data
Ki: >1.00E+4nM
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Target
Sigma non-opioid intracellular receptor 1
(RAT)
TBA
Curated by
PDSP K
i
Database
Ligand
BDBM50015720
((hyoscine)3-Hydroxy-2-phenyl-propionic acid 9-meth...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
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Target
D(1A) dopamine receptor
(RAT)
Schering-Plough
Curated by
PDSP K
i
Database
Ligand
BDBM50015720
((hyoscine)3-Hydroxy-2-phenyl-propionic acid 9-meth...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
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Target
Muscarinic acetylcholine receptor M4
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM50452855
(Isoptpo Hyoscine | Scopolamine)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.575nM
Assay Description:
Displacement of [3H]N-methylspiperone from human dopamine D4 receptor expressed in HEK293 cell membranes after 1 hr by scintillation counting method
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Target
Muscarinic acetylcholine receptor M4
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM50452855
(Isoptpo Hyoscine | Scopolamine)
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Affinity Data
IC50: 1.30nM
Assay Description:
Antagonist activity at human M4 receptor expressed in HEK293T cells assessed as inhibition of carbachol-induced response by beta-arrestin engagement ...
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Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM50452855
(Isoptpo Hyoscine | Scopolamine)
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Affinity Data
IC50: 1.5nM
Assay Description:
Displacement of [3H]N-methylspiperone from human dopamine D4 receptor expressed in HEK293 cell membranes after 1 hr by scintillation counting method
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Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM50452855
(Isoptpo Hyoscine | Scopolamine)
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Affinity Data
IC50: 1.70nM
Assay Description:
Antagonist activity at human M1 receptor expressed in HEK293T cells assessed as inhibition of carbachol-induced response by BRET based Gq protein eng...
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Copy BDB DOI
Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM50452855
(Isoptpo Hyoscine | Scopolamine)
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Affinity Data
IC50: 2.20nM
Assay Description:
Antagonist activity at human SP/Myc epitope-tagged dopamine D4 receptor expressed in HEK293T cells assessed as inhibition of dopamine-induced mVenus-...
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Copy BDB DOI
Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM50452855
(Isoptpo Hyoscine | Scopolamine)
Copy SMILES
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Affinity Data
IC50: 3.30nM
Assay Description:
Antagonist activity at human M1 receptor expressed in HEK293T cells assessed as inhibition of carbachol-induced response by BRET based beta-arrestin ...
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PubMed
Copy BDB DOI
Target
Muscarinic acetylcholine receptor M4
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM50452855
(Isoptpo Hyoscine | Scopolamine)
Copy SMILES
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Affinity Data
IC50: 3.80nM
Assay Description:
Antagonist activity at human M4 receptor expressed in HEK293T cells assessed as inhibition of carbachol-induced response by BRET based Gq protein act...
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PubMed
Copy BDB DOI
Target
Muscarinic acetylcholine receptor M4
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM50452855
(Isoptpo Hyoscine | Scopolamine)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.80nM
Assay Description:
Antagonist activity at human M4 receptor expressed in HEK293T cells assessed as inhibition of carbachol-induced response by BRET based Gq protein eng...
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(RAT)
TBA
Ligand
BDBM50452855
(Isoptpo Hyoscine | Scopolamine)
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Affinity Data
IC50: 4nM
Assay Description:
Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the absence of Zn
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NCI pathway
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(RAT)
TBA
Ligand
BDBM50452855
(Isoptpo Hyoscine | Scopolamine)
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Affinity Data
IC50: 4nM
Assay Description:
Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of Zn
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Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM50452855
(Isoptpo Hyoscine | Scopolamine)
Copy SMILES
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Affinity Data
IC50: 4.40nM
Assay Description:
Antagonist activity at human M1 receptor expressed in HEK293T cells assessed as inhibition of carbachol-induced response by BRET based Gq protein act...
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Target
Muscarinic acetylcholine receptor M4
(Homo sapiens (Human))
Mayo Clinic
Curated by
PDSP K
i
Database
Ligand
BDBM50452855
(Isoptpo Hyoscine | Scopolamine)
Copy SMILES
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Affinity Data
IC50: 5.40nM
Assay Description:
Agonist activity at human SP/Myc epitope-tagged dopamine D4 receptor expressed in HEK293T cells assessed as RLuc8-fused Galphai1 activation after 2 m...
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(RAT)
TBA
Ligand
BDBM50452855
(Isoptpo Hyoscine | Scopolamine)
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Affinity Data
IC50: 10nM
Assay Description:
Displacement of [3H]QNB from Muscarinic acetylcholine receptor of rat brain membrane
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Target
Reverse transcriptase
(Human immunodeficiency virus 1)
University Of Illinois
Curated by
ChEMBL
Ligand
BDBM50452855
(Isoptpo Hyoscine | Scopolamine)
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Affinity Data
IC50: >6.59E+5nM
Assay Description:
Inhibition of HIV1 RT
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Target
Reverse transcriptase
(Human immunodeficiency virus 1)
University Of Illinois
Curated by
ChEMBL
Ligand
BDBM50452855
(Isoptpo Hyoscine | Scopolamine)
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Affinity Data
IC50: >6.59E+5nM
Assay Description:
Inhibition of HIV1 RT
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Target
Dihydroorotate dehydrogenase (fumarate)
(Leishmania major)
University Of S£O Paulo
Curated by
ChEMBL
Ligand
BDBM50263508
(CHEMBL3084722)
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Affinity Data
IC50: 7.94E+5nM
Assay Description:
Inhibition of recombinant oligo-histidine-tagged Leishmania major DHODH expressed in Escherichia coli BL21(DE3) cells using DHO as substrate measured...
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Target
Dihydroorotate dehydrogenase (fumarate)
(Leishmania major)
University Of S£O Paulo
Curated by
ChEMBL
Ligand
BDBM50263508
(CHEMBL3084722)
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Affinity Data
IC50: 7.95E+5nM
Assay Description:
Inhibition of recombinant oligo-histidine-tagged Leishmania major DHODH expressed in Escherichia coli BL21(DE3) cells using DHO as substrate measured...
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Target
Bile salt export pump
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50452855
(Isoptpo Hyoscine | Scopolamine)
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Affinity Data
IC50: >1.00E+6nM
Assay Description:
Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...
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Target
Bile salt export pump
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50240039
(CHEBI:16794 | CHEMBL569713)
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Affinity Data
IC50: >1.00E+6nM
Assay Description:
Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...
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CHEMBL
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Target
Muscarinic acetylcholine receptor M3
(RAT)
Glaxo Group Research
Curated by
PDSP K
i
Database
Ligand
BDBM50452855
(Isoptpo Hyoscine | Scopolamine)
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Affinity Data
Kd: 0.650nM
Assay Description:
In vitro receptor binding against Muscarinic acetylcholine receptor M3 in rat submandibular gland was determined using [3H]pirenzepine
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Target
Muscarinic acetylcholine receptor M2
(RAT)
TBA
Curated by
PDSP K
i
Database
Ligand
BDBM50452855
(Isoptpo Hyoscine | Scopolamine)
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Affinity Data
Kd: 3nM
Assay Description:
In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine
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Target
Muscarinic acetylcholine receptor M1
(RAT)
Glaxo Group Research
Curated by
PDSP K
i
Database
Ligand
BDBM50452855
(Isoptpo Hyoscine | Scopolamine)
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Affinity Data
Kd: 0.75nM
Assay Description:
In vitro receptor binding against Muscarinic acetylcholine receptor M1 in rat cerebral cortex was determined using [3H]pirenzepine
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