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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 8 hits in this display   

TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140898(6-(4-bromophenyl)-19-methyl-(2R,10R)-11-oxa-8,19-d...)
Affinity DataKi:  5nMAssay Description:Binding affinity at opioid receptor delta 1 by displacement of [3H]DADLE in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140898(6-(4-bromophenyl)-19-methyl-(2R,10R)-11-oxa-8,19-d...)
Affinity DataKi:  91nMAssay Description:Binding affinity at Opioid receptor kappa 1 by displacement of [3H]U-69593 in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140898(6-(4-bromophenyl)-19-methyl-(2R,10R)-11-oxa-8,19-d...)
Affinity DataKi:  200nMAssay Description:Binding affinity at Opioid receptor mu 1 by displacement of [3H]DAMGO in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140898(6-(4-bromophenyl)-19-methyl-(2R,10R)-11-oxa-8,19-d...)
Affinity DataKi:  265nMAssay Description:Apparent binding affinity of compound was determined by antagonism towards Opioid receptor kappa 1 in [35S]GTP-gamma-S, binding assay in guinea pig c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140898(6-(4-bromophenyl)-19-methyl-(2R,10R)-11-oxa-8,19-d...)
Affinity DataKi: >1.00E+3nMAssay Description:Apparent binding affinity of compound was determined by antagonism towards Opioid receptor mu 1 in [35S]GTP-gamma-S, binding assay in guinea pig caud...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140898(6-(4-bromophenyl)-19-methyl-(2R,10R)-11-oxa-8,19-d...)
Affinity DataIC50:  55nMAssay Description:Inhibitory concentration required for 50% inhibition of antagonism towards opioid receptor delta 1 in [35S]GTP-gamma-S, binding assay in guinea pig c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140898(6-(4-bromophenyl)-19-methyl-(2R,10R)-11-oxa-8,19-d...)
Affinity DataIC50:  666nMAssay Description:Inhibitory concentration for inhibition of Opioid receptor mu 1 induced contractions in guinea pig ileum (GPI) smooth muscle assaysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140898(6-(4-bromophenyl)-19-methyl-(2R,10R)-11-oxa-8,19-d...)
Affinity DataEC50:  3.22E+3nMAssay Description:Agonistic activity towards Opioid receptor mu 1 was determined in [35S]GTP-gamma-S, binding assay in guinea pig caudate; g = not active as an agonistMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed