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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 9 hits in this display   

TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140910(19-methyl-(2R,10R)-11-oxa-8,19-diazahexacyclo[10.9...)
Affinity DataKi:  8nMAssay Description:Binding affinity at opioid receptor delta 1 by displacement of [3H]DADLE in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140910(19-methyl-(2R,10R)-11-oxa-8,19-diazahexacyclo[10.9...)
Affinity DataKi:  13nMAssay Description:Binding affinity at Opioid receptor mu 1 by displacement of [3H]DAMGO in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140910(19-methyl-(2R,10R)-11-oxa-8,19-diazahexacyclo[10.9...)
Affinity DataKi:  66nMAssay Description:Binding affinity at Opioid receptor kappa 1 by displacement of [3H]U-69593 in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140910(19-methyl-(2R,10R)-11-oxa-8,19-diazahexacyclo[10.9...)
Affinity DataKi:  595nMAssay Description:Apparent antagonist activity determined by measuring the ability to inhibit stimulation of [35S]GTP-gamma-S, binding to opioid receptor delta 1 in gu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140910(19-methyl-(2R,10R)-11-oxa-8,19-diazahexacyclo[10.9...)
Affinity DataKi: >1.00E+3nMAssay Description:Apparent binding affinity of compound was determined by antagonism towards Opioid receptor mu 1 in [35S]GTP-gamma-S, binding assay in guinea pig caud...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140910(19-methyl-(2R,10R)-11-oxa-8,19-diazahexacyclo[10.9...)
Affinity DataKi: >1.00E+3nMAssay Description:Apparent binding affinity of compound was determined by antagonism towards Opioid receptor kappa 1 in [35S]GTP-gamma-S, binding assay in guinea pig c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140910(19-methyl-(2R,10R)-11-oxa-8,19-diazahexacyclo[10.9...)
Affinity DataIC50:  68nMAssay Description:Inhibitory concentration for inhibition of Opioid receptor mu 1 induced contractions in guinea pig ileum (GPI) smooth muscle assaysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140910(19-methyl-(2R,10R)-11-oxa-8,19-diazahexacyclo[10.9...)
Affinity DataIC50:  152nMAssay Description:Inhibitory concentration required for 50 percent inhibition of opioid receptor delta 1 induced contractions in mouse vas deferens (MVD) smooth muscle...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140910(19-methyl-(2R,10R)-11-oxa-8,19-diazahexacyclo[10.9...)
Affinity DataEC50:  3.00E+3nMAssay Description:Agonistic activity towards Opioid receptor mu 1 was determined in [35S]GTP-gamma-S, binding assay in guinea pig caudateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed