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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 7 hits in this display   

TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM27890(8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[2-(4-methylpi...)
Affinity DataIC50:  0.800nMpH: 7.5 T: 2°CAssay Description:FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...More data for this Ligand-Target Pair
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TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM27890(8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[2-(4-methylpi...)
Affinity DataIC50:  1nMT: 2°CAssay Description:FLT-3 was assayed using a fluorescence polarization (FP) competition immunoassay that measured FLT-3 phosphorylation of polyGlu4Tyr. The reaction was...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM27890(8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[2-(4-methylpi...)
Affinity DataIC50:  8nMAssay Description:Inhibition of ATP-induced CSF1R autophosphorylationMore data for this Ligand-Target Pair
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TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM27890(8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[2-(4-methylpi...)
Affinity DataIC50:  20nMT: 2°CAssay Description:KIT was assayed using a fluorescence polarization (FP) competition immunoassay that measured KIT phosphorylation of polyGlu4Tyr. The reaction was ini...More data for this Ligand-Target Pair
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TargetHigh affinity nerve growth factor receptor [440-796](Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM27890(8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[2-(4-methylpi...)
Affinity DataIC50:  170nMT: 2°CAssay Description:TrkA was assayed using a fluorescence polarization (FP) competition immunoassay that measured TrkA phosphorylation of polyGlu4Tyr. The reaction was i...More data for this Ligand-Target Pair
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TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM27890(8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[2-(4-methylpi...)
Affinity DataIC50: >500nMT: 2°CAssay Description:Axl was assayed using a fluorescence polarization (FP) competition immunoassay that measured Axl phosphorylation of polyGlu4Tyr. The reaction was ini...More data for this Ligand-Target Pair
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TargetInsulin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM27890(8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[2-(4-methylpi...)
Affinity DataIC50: >4.20E+4nMT: 2°CAssay Description:IRKbeta was assayed using a fluorescence polarization (FP) competition immunoassay that measured IRKbeta phosphorylation of polyGlu4Tyr. The reaction...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed