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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
4
hits in this display
Target
Disintegrin and metalloproteinase domain-containing protein 17
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50069608
((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-1-methyl...)
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Affinity Data
IC50: 1.80nM
Assay Description:
Inhibitory activity against Tumor necrosis factor alpha-converting enzyme (TACE) in blood.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
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Target
Interstitial collagenase
(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50069608
((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-1-methyl...)
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Affinity Data
IC50: 20nM
Assay Description:
Inhibitory activity of the compound towards human recombinant fibroblast collagenase
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Low affinity immunoglobulin epsilon Fc receptor
(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50069608
((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-1-methyl...)
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Affinity Data
IC50: 40nM
Assay Description:
Tested for inhibition against CD23 (IgE receptor) proteolysis in membranes derived from RPM18866 cells ( a human B-cell line); value ranges from 40-8...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Disintegrin and metalloproteinase domain-containing protein 17
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50069608
((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-1-methyl...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5.30E+3nM
Assay Description:
Inhibition of TNF(tumor necrosis factor) in human blood
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI