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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
5
hits in this display
Target
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human))
Bayer Research Center
Curated by
ChEMBL
Ligand
BDBM50215763
(1-methyl-3-(5-((1-methyl-4-((4-(trifluoromethylthi...)
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Affinity Data
IC50: 15nM
Assay Description:
Inhibition of pAkt
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human))
Bayer Research Center
Curated by
ChEMBL
Ligand
BDBM50215763
(1-methyl-3-(5-((1-methyl-4-((4-(trifluoromethylthi...)
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Affinity Data
IC50: 17nM
Assay Description:
Inhibition of human recombinant cKit by FRET assay
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human))
Bayer Research Center
Curated by
ChEMBL
Ligand
BDBM50215763
(1-methyl-3-(5-((1-methyl-4-((4-(trifluoromethylthi...)
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Affinity Data
IC50: 62nM
Assay Description:
Inhibition of VEGFR2
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human))
Bayer Research Center
Curated by
ChEMBL
Ligand
BDBM50215763
(1-methyl-3-(5-((1-methyl-4-((4-(trifluoromethylthi...)
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Affinity Data
IC50: 154nM
Assay Description:
Inhibition of b-Raf
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human))
Bayer Research Center
Curated by
ChEMBL
Ligand
BDBM50215763
(1-methyl-3-(5-((1-methyl-4-((4-(trifluoromethylthi...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 899nM
Assay Description:
Inhibition of P-ERK
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI